HitPredict

Interactor 1: CBX5 (Q61686)
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: Q9DCC5 (Q9DCC5)
Cbx3 protein (Chromobox 3)
Gene: Cbx3

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29795351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~Chromo, Chromo_shadow~Chromo_shadow
Common GO terms	GO:0006974 - DNA damage response GO:0045892 - negative regulation of DNA-templated transcription GO:0090734 - site of DNA damage
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 191 Mm			1 183
+	Hs
		853244 CBX5_HUMAN (1-191): 2.9e-69: 210: 97.91		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1097266 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Mm
		1223211 CBX5_MOUSE (1-191): 1.81e-69: 211: 100.00		CBX5_MOUSE (11-182): 1.22e-55: 175: 59.89
+	Hs
		853189 CBX5_HUMAN (1-191): 2.9e-69: 210: 97.91		CBX5_HUMAN (11-182): 1.63e-55: 175: 59.89
+	Mm
		1014252 CBX5_MOUSE (1-191): 1.81e-69: 211: 100.00		CBX1_MOUSE (36-180): 1.03e-53: 170: 71.33
+	Hs
		853225 CBX5_HUMAN (1-191): 2.9e-69: 210: 97.91		CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33
+	Hs
		1014085 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		CBX1_HUMAN (36-180): 1.03e-53: 170: 71.33
+	Mm
		1014278 Q9DCC5_MOUSE (1-181): 5e-62: 192: 60.22		CBX1_MOUSE (36-180): 1.03e-53: 170: 71.33
+	Hs
		1434610 V9HWG0_HUMAN (1-191): 2.9e-69: 210: 97.91		SUV92_HUMAN (6-156): 4.06e-43: 149: 25.15
+	Hs
		853409 CBX5_HUMAN (1-191): 2.9e-69: 210: 97.91		SUV92_HUMAN (6-156): 4.06e-43: 149: 25.15
+	Mm
		236521 CBX5_MOUSE (1-191): 1.81e-69: 211: 100.00		SUV91_MOUSE (3-179): 2.62e-41: 145: 17.32
+	Hs
		216389 CBX5_HUMAN (1-191): 2.9e-69: 210: 97.91		SUV91_HUMAN (3-179): 4.75e-40: 141: 16.20
+	Hs
		216574 V9HWG0_HUMAN (1-191): 2.9e-69: 210: 97.91		SUV91_HUMAN (3-179): 4.75e-40: 141: 16.20
+	Hs
		1097562 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		SUV92_HUMAN (6-156): 4.06e-43: 149: 25.15
+	Mm
		236522 Q9DCC5_MOUSE (1-181): 5e-62: 192: 60.22		SUV91_MOUSE (3-179): 2.62e-41: 145: 17.32
+	Hs
		216425 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		SUV91_HUMAN (3-179): 4.75e-40: 141: 16.20
+	Hs
		1097638 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		CDYL_HUMAN (16-165): 6.56e-34: 127: 25.16
+	Hs
		338836 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		CBX6_HUMAN (21-124): 3.32e-27: 107: 27.78
+	Hs
		1097575 CBX3_HUMAN (1-181): 5e-62: 192: 60.22		CBX8_HUMAN (21-116): 2.35e-26: 104: 32.00