HitPredict

Interactor 1: LTBP4 (Q8N2S1)
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
Gene: LTBP4

Interactor 2: OIT3 (Q8WWZ8)
Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein)
Gene: OIT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1624 Hs			1 545
+	Hs
		1231807 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN5_HUMAN (86-393): 2.73e-43: 161: 20.25
+	Hs
		724347 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBN1_HUMAN (94-252): 1.54e-12: 72.9: 24.70
+	Hs
		612884 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN1_HUMAN (63-216): 1.31e-11: 69.4: 21.11
+	Hs
		1059076 LTBP4_HUMAN (1-1624): 0: 640: 100.00		LTBP2_HUMAN (149-222): 4.33e-09: 61.4: 28.21
+	Hs
		1059044 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		LTBP1_HUMAN (135-365): 2.94e-22: 103: 15.92
+	Hs
		612912 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		FBLN1_HUMAN (63-216): 1.31e-11: 69.4: 21.11
+	Hs
		804372 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC1_HUMAN (5-356): 8.24e-10: 64.2: 9.55
+	Dr
		804161 NOTC1_DANRE (463-1624): 4.14e-95: 344: 17.18		Q1A5L2_DANRE (216-383): 2.53e-11: 68.8: 9.61
+	Hs
		957265 FBLN2_HUMAN (514-1010): 7.98e-43: 173: 35.15		FBLN3_HUMAN (56-283): 9.81e-31: 127: 17.55
+	Hs
		980375 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		LTBP1_HUMAN (135-365): 2.94e-22: 103: 15.92
+	Hs
		957267 FBLN2_HUMAN (514-1010): 7.98e-43: 173: 35.15		LTBP1_HUMAN (135-365): 2.94e-22: 103: 15.92
+	Mm
		140128 LTBP2_MOUSE (849-1619): 2.62e-23: 110: 15.58		FBLN5_MOUSE (86-393): 3.25e-44: 164: 20.89
+	Hs
		724367 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBN2_HUMAN (18-252): 8.87e-13: 73.8: 19.09
+	Hs
		612843 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBLN1_HUMAN (63-216): 1.31e-11: 69.4: 21.11
+	Hs
		804213 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		NOTC1_HUMAN (5-356): 8.24e-10: 64.2: 9.55
+	Hs
		724337 FBLN2_HUMAN (514-1010): 7.98e-43: 173: 35.15		FBN1_HUMAN (94-252): 1.54e-12: 72.9: 24.70
+	Hs
		957262 FBLN2_HUMAN (514-1010): 7.98e-43: 173: 35.15		FBLN2_HUMAN (11-195): 7.64e-10: 63.7: 14.49
+	Hs
		612820 FBLN1_HUMAN (549-742): 2.84e-22: 105: 36.23		FBLN1_HUMAN (63-216): 1.31e-11: 69.4: 21.11
+	Dm
		90684 E1JHA6_DROME (16-472): 4.37e-23: 110: 10.24		NOTCH_DROME (2-360): 1.23e-09: 63.4: 11.11
+	Hs
		804163 NOTC1_HUMAN (1220-1624): 1.98e-22: 107: 13.06		NOTC1_HUMAN (5-356): 8.24e-10: 64.2: 9.55