Protein: RUSC1
AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1)

Gene: RUSC1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9BVN2

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

254490

PLPL9
85/88 kDa calcium-independent phospholipase A2

2

0

High-throughput

0.742

High

842929

CDN2B
Cyclin-dependent kinase 4 inhibitor B

2

0

High-throughput

0.742

High

1372064

RBPMS
RNA-binding protein with multiple splicing

4

0

High-throughput

0.668

High

1336456

PNMA1
Paraneoplastic antigen Ma1

4

1

High-throughput

0.639

High

1366027

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

1

High-throughput

0.621

High

1415517

GIT1
ARF GTPase-activating protein GIT1

1

1

High-throughput

0.618

High

848297

MAGA3
Melanoma-associated antigen 3

2

3

High-throughput

0.606

High

848435

MAGA6
Melanoma-associated antigen 6

2

3

High-throughput

0.606

High

913029

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

2

High-throughput

0.606

High

1156051

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.606

High

1253082

ZN620
Zinc finger protein 620

2

1

High-throughput

0.606

High

1385136

MOAP1
Modulator of apoptosis 1

2

1

High-throughput

0.606

High

1415504

PRD14
PR domain zinc finger protein 14

2

2

High-throughput

0.606

High

1415520

MAGD1
Melanoma-associated antigen D1

2

2

High-throughput

0.606

High

1316976

FAM9B
Protein FAM9B

2

0

High-throughput

0.601

High

71145

VGLL3
Transcription cofactor vestigial-like protein 3

2

0

High-throughput

0.580

High

163471

MEIS2
Homeobox protein Meis2

2

0

High-throughput

0.580

High

175989

N4BP3
NEDD4-binding protein 3

2

0

High-throughput

0.580

High

180378

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

217191

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

288316

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.580

High

296000

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.580

High

666902

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

681911

RBTN2
Rhombotin-2

2

0

High-throughput

0.580

High

1040644

CREM
cAMP-responsive element modulator

2

0

High-throughput

0.580

High

1061855

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1086689

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

0

High-throughput

0.580

High

1156088

ZNF77
Zinc finger protein 77

2

0

High-throughput

0.580

High

1186696

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1186910

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.580

High

1187134

TBC25
TBC1 domain family member 25

2

0

High-throughput

0.580

High

1207257

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.580

High

1238973

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.580

High

1244213

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

1245797

DOK6
Docking protein 6

2

0

High-throughput

0.580

High

1259277

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.580

High

1271970

ZN765
Zinc finger protein 765

2

0

High-throughput

0.580

High

1287589

TTC7B
Tetratricopeptide repeat protein 7B

2

0

High-throughput

0.580

High

1307013

KR191
Keratin-associated protein 19-1

2

0

High-throughput

0.580

High

1307090

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.580

High

1315123

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.580

High

1331447

VA0D2
V-type proton ATPase subunit d 2

2

0

High-throughput

0.580

High

1332935

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

0

High-throughput

0.580

High

1350713

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.580

High

1350972

MYOZ3
Myozenin-3

2

0

High-throughput

0.580

High

1355977

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

2

0

High-throughput

0.580

High

1358991

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

1364865

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.580

High

1381899

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

1384015

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

1392878

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1404658

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

1408107

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1412408

NICN1
Nicolin-1

2

0

High-throughput

0.580

High

1413264

TCHP
Trichoplein keratin filament-binding protein

2

0

High-throughput

0.580

High

1415507

HM20A
High mobility group protein 20A

2

0

High-throughput

0.580

High

1415509

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.580

High

1415510

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1415512

ABI2
Abl interactor 2

2

0

High-throughput

0.580

High

1415513

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1415515

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

1231789

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

4

High-throughput

0.553

High

1278563

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

1

High-throughput

0.553

High

1339528

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

2

1

High-throughput

0.553

High

132276

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.549

High

1415516

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.549

High

1380841

TRI63
E3 ubiquitin-protein ligase TRIM63

1

1

High-throughput

0.541

High

1415503

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.541

High

938791

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

2

High-throughput

0.536

High

1415522

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.525

High

1289122

TRI74
Tripartite motif-containing protein 74

1

1

High-throughput

0.515

High

1162695

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

High-throughput

0.513

High

1415521

NPTN
Neuroplastin

1

0

High-throughput

0.513

High

1415518

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.493

High

1025140

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

159828

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.486

High

1289132

TRI73
Tripartite motif-containing protein 73

1

1

High-throughput

0.481

High

161078

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

0

Small-scale

0.480

High

423054

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

749995

KINH
Kinesin-1 heavy chain

1

2

Small-scale

0.479

High

1060568

KLC1
Kinesin light chain 1

1

3

Small-scale

0.479

High

1276296

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1415514

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1193624

Q49AR9
ANKS1A protein

1

1

High-throughput

0.470

High

1315913

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

953068

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

1415508

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1227378

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

506767

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

511025

LIMS4
LIM and senescent cell antigen-like-containing domain protein 4

2

0

High-throughput

0.316

High

907188

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

922367

CRBA2
Beta-crystallin A2

2

0

High-throughput

0.316

High

1006297

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.316

High

1169079

INSC
Protein inscuteable homolog

2

0

High-throughput

0.316

High

1180016

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

1198276

FND3B
Fibronectin type III domain-containing protein 3B

2

0

High-throughput

0.316

High

1271404

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1289293

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

1309154

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.316

High

1315431

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.316

High

1392983

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1399892

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1411582

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

0

High-throughput

0.316

High

1415505

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1415506

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1415511

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

2

0

High-throughput

0.316

High

1253930

FA83H
Protein FAM83H

1

0

High-throughput

0.279

Low

1031946

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

1415519

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025