Protein: RUSC2
AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2)

Gene: RUSC2
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q8N2Y8

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0031267 - small GTPase binding
GO:0031410 - cytoplasmic vesicle
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

981313

RAB1A
Ras-related protein Rab-1A

1

1

Small-scale

0.733

High

1324623

RAB1B
Ras-related protein Rab-1B

1

1

Small-scale

0.675

High

1049548

1433F
14-3-3 protein eta

2

6

High-throughput

0.611

High

363564

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

1324622

KLC2
Kinesin light chain 2

1

3

Small-scale

0.552

High

788098

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.518

High

900031

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

808117

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

913354

MSH6
DNA mismatch repair protein Msh6

1

0

High-throughput

0.513

High

1126857

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

0

High-throughput

0.513

High

1134278

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

1324621

KIFA3
Kinesin-associated protein 3

1

0

High-throughput

0.513

High

620472

NUCL
Nucleolin

1

0

High-throughput

0.493

High

1122416

GIT2
ARF GTPase-activating protein GIT2

1

1

High-throughput

0.481

High

173061

XPO1
Exportin-1

1

3

High-throughput

0.479

High

691235

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

730046

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

730761

1433S
14-3-3 protein sigma

1

6

High-throughput

0.479

High

749966

KINH
Kinesin-1 heavy chain

1

2

Small-scale

0.479

High

966602

1433G
14-3-3 protein gamma

1

6

High-throughput

0.479

High

990487

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

1060545

KLC1
Kinesin light chain 1

1

3

Small-scale

0.479

High

1227052

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1324624

XPO7
Exportin-7

1

2

High-throughput

0.479

High

254471

MAGC1
Melanoma-associated antigen C1

1

3

Small-scale

0.464

High

786720

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

920109

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

971771

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1115295

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

1226169

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

1252330

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

191366

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

1

High-throughput

0.445

High

469135

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.438

High

323045

WDR47
WD repeat-containing protein 47

1

2

Small-scale

0.437

High

1276213

ATG9A
Autophagy-related protein 9A

1

1

Small-scale

0.437

High

844828

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1023831

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

1059895

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.391

High

1063425

GOGA2
Golgin subfamily A member 2

1

0

Small-scale

0.288

High

719028

WEE1
Wee1-like protein kinase

1

0

High-throughput

0.279

Low

945899

INHBE
Inhibin beta E chain

1

0

High-throughput

0.232

Low

1324620

NET5
Netrin-5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025