HitPredict

Interactor 1: TM199 (Q8N511)
Transmembrane protein 199
Gene: TMEM199

Interactor 2: VPP1 (Q93050)
V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)
Gene: ATP6V0A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007042 - lysosomal lumen acidification GO:0016471 - vacuolar proton-transporting V-type ATPase complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 208 Hs			1 837
+	Hs
		1234083 TM199_HUMAN (1-208): 1.4e-114: 326: 100.00		VPP4_HUMAN (1-837): 0: 1240: 61.16
+	Hs
		1234103 TM199_HUMAN (1-208): 1.4e-114: 326: 100.00		VPP2_HUMAN (1-830): 0: 1177: 53.53
+	Hs
		1035674 TM199_HUMAN (1-208): 1.4e-114: 326: 100.00		VPP3_HUMAN (1-829): 0: 1068: 46.86
+	Dm
		1213059 Q8SXS0_DROME (22-201): 8.27e-78: 236: 28.04		Q8IML3_DROME (1-832): 0: 1152: 60.26