Interactor 1: PCSK9 (Q8NBP7)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Gene: PCSK9
Interactor 2: PCSK9 (Q8NBP7)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Gene: PCSK9
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.41 | 1.00 | 0.647 |
The method score is based on:
Property | Details |
---|---|
Experiments | 17804797 |
Identification Methods | x-ray crystallography |
Interaction Type | direct interaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Inhibitor_I9~Peptidase_S8, PCSK9_C1~PCSK9_C2, PCSK9_C1~PCSK9_C3, PCSK9_C1~Peptidase_S8, PCSK9_C2~PCSK9_C3, Peptidase_S8~Peptidase_S8 |
Common GO terms | GO:0001822 - kidney development GO:0001889 - liver development GO:0001920 - negative regulation of receptor recycling GO:0002091 - negative regulation of receptor internalization GO:0002092 - positive regulation of receptor internalization and 50 others more... |
Homologous interactions | 13 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024