Interactor 1: PCSK9 (Q8NBP7)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Gene: PCSK9

Interactor 2: PCSK9 (Q8NBP7)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Gene: PCSK9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 17804797
Identification Methods x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Inhibitor_I9~Peptidase_S8, PCSK9_C1~PCSK9_C2, PCSK9_C1~PCSK9_C3, PCSK9_C1~Peptidase_S8, PCSK9_C2~PCSK9_C3, Peptidase_S8~Peptidase_S8
Common GO terms GO:0001822 - kidney development
GO:0001889 - liver development
GO:0001920 - negative regulation of receptor recycling
GO:0002091 - negative regulation of receptor internalization
GO:0002092 - positive regulation of receptor internalization
and 50 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 692
Hs

1 692
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Last updated: 15 Jul 2024