HitPredict

Interactor 1: KREM2 (Q8NCW0)
Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)
Gene: KREMEN2

Interactor 2: KLK15 (Q9H2R5)
Kallikrein-15 (EC 3.4.21.-) (ACO protease)
Gene: KLK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Kringle~Trypsin
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 462 Hs			1 256
+	Hs
		884421 NETO2_HUMAN (203-450): 1.16e-45: 168: 16.98		TMPS3_HUMAN (4-256): 1.1e-101: 305: 30.45
+	Hs
		155388 NRP1_HUMAN (215-458): 9.54e-50: 183: 17.47		TM11B_HUMAN (12-252): 2.35e-92: 279: 33.33
+	Hs
		428714 BMP1_HUMAN (40-331): 4.63e-25: 110: 14.67		TRY2_HUMAN (1-256): 1.13e-114: 330: 41.41
+	Hs
		528132 BMP1_HUMAN (40-331): 4.63e-25: 110: 14.67		KLK15_HUMAN (1-256): 3.74e-114: 329: 100.00
+	Hs
		528072 BMP1_HUMAN (40-331): 4.63e-25: 110: 14.67		KLK2_HUMAN (1-256): 2.8e-108: 314: 39.63
+	Hs
		341481 UROK_HUMAN (33-120): 6.41e-26: 111: 34.44		KLK1_HUMAN (1-256): 2.74e-106: 309: 37.64
+	Hs
		589595 ROR2_HUMAN (15-120): 1.5e-21: 100: 28.32		KLK2_HUMAN (1-256): 2.8e-108: 314: 39.63
+	Hs
		836343 PCOC2_HUMAN (171-331): 1.04e-26: 113: 18.75		KLK7_HUMAN (13-255): 1.69e-101: 297: 41.98
+	Hs
		409570 PCOC2_HUMAN (171-331): 1.04e-26: 113: 18.75		HEPS_HUMAN (4-254): 5.24e-98: 294: 30.55
+	Hs
		341531 TPA_HUMAN (20-133): 5.62e-23: 103: 31.03		HEPS_HUMAN (4-254): 5.24e-98: 294: 30.55
+	Hs
		225107 HGFL_HUMAN (35-204): 2.82e-16: 83.4: 22.81		TM11D_HUMAN (19-253): 7.22e-100: 298: 33.47
+	Hs
		198481 DMBT1_HUMAN (98-334): 2.26e-25: 111: 15.04		KLK10_HUMAN (25-256): 3.92e-60: 192: 41.67
+	Mm
		371793 NRP1_MOUSE (175-372): 1.29e-27: 118: 18.27		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		192661 NRP2_MOUSE (115-337): 2.83e-27: 117: 19.11		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		372177 C1RB_MOUSE (225-444): 2.97e-23: 105: 14.79		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		371510 TPA_MOUSE (34-132): 3.44e-22: 101: 31.68		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40