Protein: KLDC3
Kelch domain-containing protein 3 (Testis intracellular mediator protein)

Gene: KLDC3, KLHDC3
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9BQ90

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1112971

CUL2
Cullin-2

7

20

Small-scale

0.746

High

1154916

NEDD8
Ubiquitin-like protein NEDD8

5

4

Small-scale

0.703

High

1308580

NUDC3
NudC domain-containing protein 3

4

20

High-throughput

0.691

High

1147112

ELOC
Elongin-C

4

2

Small-scale

0.683

High

1147260

ELOB
Elongin-B

4

4

Small-scale

0.672

High

320763

UBXN7
UBX domain-containing protein 7

3

6

High-throughput

0.667

High

958703

CSN2
COP9 signalosome complex subunit 2

3

18

High-throughput

0.667

High

1017476

FOXK1
Forkhead box protein K1

3

5

High-throughput

0.667

High

1131111

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

3

2

High-throughput

0.667

High

1272538

CSN6
COP9 signalosome complex subunit 6

3

9

High-throughput

0.667

High

1278921

BRAP
BRCA1-associated protein

3

5

High-throughput

0.667

High

1292804

SKAP1
Src kinase-associated phosphoprotein 1

3

6

High-throughput

0.667

High

1394880

EAF1
ELL-associated factor 1

3

1

High-throughput

0.667

High

1409534

DPYL5
Dihydropyrimidinase-related protein 5

3

5

High-throughput

0.667

High

1410292

ARI1
E3 ubiquitin-protein ligase ARIH1

3

12

High-throughput

0.667

High

290345

KS6A4
Ribosomal protein S6 kinase alpha-4

3

4

High-throughput

0.662

High

1289972

LUZP1
Leucine zipper protein 1

3

15

High-throughput

0.662

High

1371184

GLMN
Glomulin

3

3

High-throughput

0.662

High

294947

POP7
Ribonuclease P protein subunit p20

4

0

High-throughput

0.661

High

1368746

SYMPK
Symplekin

4

0

High-throughput

0.661

High

1410283

MOCS1
Molybdenum cofactor biosynthesis protein 1

4

0

High-throughput

0.661

High

983951

RBX1
E3 ubiquitin-protein ligase RBX1

3

9

Small-scale

0.656

High

1410286

TSYL4
Testis-specific Y-encoded-like protein 4

3

0

High-throughput

0.638

High

155875

DPYL4
Dihydropyrimidinase-related protein 4

2

5

High-throughput

0.628

High

936435

AFAD
Afadin

2

9

High-throughput

0.628

High

960858

RL15
Large ribosomal subunit protein eL15

2

2

High-throughput

0.628

High

1104658

IKZF1
DNA-binding protein Ikaros

2

1

High-throughput

0.628

High

1395277

LCOR
Ligand-dependent corepressor

2

1

High-throughput

0.628

High

1407152

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

1

High-throughput

0.628

High

1410277

WDR55
WD repeat-containing protein 55

2

6

High-throughput

0.628

High

1410288

G3BP2
Ras GTPase-activating protein-binding protein 2

2

4

High-throughput

0.628

High

270975

CLAP2
CLIP-associating protein 2

2

3

High-throughput

0.611

High

1158699

DPYL2
Dihydropyrimidinase-related protein 2

2

5

High-throughput

0.611

High

1371849

CUL5
Cullin-5

2

20

Small-scale

0.611

High

1410275

DIDO1
Death-inducer obliterator 1

2

17

High-throughput

0.611

High

1328035

RP25L
Ribonuclease P protein subunit p25-like protein

3

1

High-throughput

0.609

High

1410281

4ET
Eukaryotic translation initiation factor 4E transporter

2

0

High-throughput

0.602

High

1410282

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

High-throughput

0.602

High

1410287

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

212686

DAPK3
Death-associated protein kinase 3

2

4

High-throughput

0.601

High

273095

CLU
Clustered mitochondria protein homolog

2

2

High-throughput

0.601

High

1309151

MISP
Mitotic interactor and substrate of PLK1

2

3

High-throughput

0.574

High

1410280

CRAC1
Cartilage acidic protein 1

2

3

High-throughput

0.574

High

1410276

CAD19
Cadherin-19

2

11

High-throughput

0.558

High

1410291

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

3

High-throughput

0.558

High

139408

VMA5A
von Willebrand factor A domain-containing protein 5A

1

1

High-throughput

0.536

High

216527

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

4

High-throughput

0.536

High

261438

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

5

High-throughput

0.536

High

391431

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

543539

VDR
Vitamin D3 receptor

1

6

High-throughput

0.536

High

800073

COIL
Coilin

1

1

High-throughput

0.536

High

885880

KC1E
Casein kinase I isoform epsilon

1

8

High-throughput

0.536

High

1370332

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1382520

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

1394576

THOC3
THO complex subunit 3

1

5

High-throughput

0.536

High

1398872

ZN641
Zinc finger protein 641

1

1

High-throughput

0.536

High

1406118

CSN8
COP9 signalosome complex subunit 8

1

4

High-throughput

0.536

High

1410278

CSN7B
COP9 signalosome complex subunit 7b

1

4

High-throughput

0.536

High

1410289

CSN3
COP9 signalosome complex subunit 3

1

18

High-throughput

0.536

High

1368715

DLG3
Disks large homolog 3

1

1

High-throughput

0.515

High

69405

WASH1
WASH complex subunit 1

1

0

High-throughput

0.513

High

635371

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.513

High

1277617

K1C27
Keratin, type I cytoskeletal 27

1

0

High-throughput

0.513

High

1410274

RTKN
Rhotekin

1

0

High-throughput

0.513

High

508524

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

190472

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

1322351

ZN444
Zinc finger protein 444

1

6

High-throughput

0.489

High

1323703

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

3

High-throughput

0.489

High

1410284

FBLN5
Fibulin-5

1

4

High-throughput

0.489

High

1331356

ENAH
Protein enabled homolog

1

5

High-throughput

0.481

High

173281

XPO1
Exportin-1

1

7

High-throughput

0.479

High

842846

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

Small-scale

0.479

High

957493

UBC12
NEDD8-conjugating enzyme Ubc12

1

15

High-throughput

0.479

High

1410279

MYO10
Unconventional myosin-X

1

14

Small-scale

0.479

High

1410285

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

194316

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

95699

E3W994
Cytoplasmic linker associated protein 2

1

3

High-throughput

0.445

High

839617

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.445

High

884388

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

6

High-throughput

0.445

High

1410290

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.445

High

193865

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

2

High-throughput

0.407

High

1152778

KISS1
Metastasis-suppressor KiSS-1

1

1

High-throughput

0.407

High

1310936

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

1396486

Q96KY9
CDH19 protein

1

10

High-throughput

0.407

High

1391122

HMCES
Abasic site processing protein HMCES

2

0

High-throughput

0.328

High

1241203

CC033
Protein C3orf33

2

0

High-throughput

0.318

High

1326733

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

0

High-throughput

0.313

High

1293584

MICU3
Calcium uptake protein 3, mitochondrial

1

0

High-throughput

0.279

Low

219419

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

High-throughput

0.249

Low

125970

SMAP
Small acidic protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025