Protein: FOXO3
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)

Gene: FOXO3
Organism: Homo sapiens
Interactions: 94
UniProt ID: O43524

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206847

CBP
CREB-binding protein

4

20

Small-scale

0.902

High

206831

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.847

High

206807

1433B
14-3-3 protein beta/alpha

7

20

Small-scale

0.747

High

206822

1433Z
14-3-3 protein zeta/delta

8

20

Small-scale

0.747

High

206820

1433E
14-3-3 protein epsilon

5

6

Small-scale

0.716

High

206825

FOXK1
Forkhead box protein K1

1

20

High-throughput

0.715

High

206829

1433F
14-3-3 protein eta

5

20

High-throughput

0.709

High

206850

SIR1
NAD-dependent protein deacetylase sirtuin-1

4

13

Small-scale

0.704

High

206819

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

206799

1433T
14-3-3 protein theta

4

20

Small-scale

0.683

High

206827

MDM2
E3 ubiquitin-protein ligase Mdm2

4

4

Small-scale

0.676

High

206834

SKP2
S-phase kinase-associated protein 2

3

4

Small-scale

0.664

High

206837

SMAD4
Mothers against decapentaplegic homolog 4

2

18

Small-scale

0.654

High

206806

AKT1
RAC-alpha serine/threonine-protein kinase

3

12

Small-scale

0.651

High

206788

P53
Cellular tumor antigen p53

3

15

Small-scale

0.646

High

206824

SMAD3
Mothers against decapentaplegic homolog 3

2

18

Small-scale

0.641

High

206817

PLK1
Serine/threonine-protein kinase PLK1

2

8

Small-scale

0.634

High

158350

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

8

Small-scale

0.624

High

206835

ATM
Serine-protein kinase ATM

2

9

Small-scale

0.624

High

206830

FOXM1
Forkhead box protein M1

1

20

Small-scale

0.618

High

206846

ESR2
Estrogen receptor beta

2

20

Small-scale

0.612

High

167422

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.608

High

206840

PTPA
Serine/threonine-protein phosphatase 2A activator

2

1

Small-scale

0.595

High

206803

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

Small-scale

0.588

High

206853

ATGA1
Autophagy-related protein 101

2

0

Small-scale

0.585

High

206797

H2AX
Histone H2AX

2

7

Small-scale

0.584

High

206809

CTNB1
Catenin beta-1

2

13

Small-scale

0.584

High

206849

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

9

Small-scale

0.584

High

206862

FBW1A
F-box/WD repeat-containing protein 1A

1

17

Small-scale

0.578

High

68639

FOXO6
Forkhead box protein O6

1

16

High-throughput

0.575

High

206778

FOXO3
Forkhead box protein O3

1

19

High-throughput

0.575

High

206821

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

3

Small-scale

0.571

High

206826

CDK6
Cyclin-dependent kinase 6

1

12

Small-scale

0.569

High

153967

TERT
Telomerase reverse transcriptase

1

1

Small-scale

0.561

High

206794

VDR
Vitamin D3 receptor

1

20

Small-scale

0.561

High

206800

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.561

High

206838

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

Small-scale

0.561

High

206780

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

13

High-throughput

0.554

High

206789

RB
Retinoblastoma-associated protein

1

9

High-throughput

0.554

High

206801

RBL1
Retinoblastoma-like protein 1

1

9

High-throughput

0.554

High

206805

CDC27
Cell division cycle protein 27 homolog

1

3

High-throughput

0.554

High

206848

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

High-throughput

0.554

High

206852

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

1

High-throughput

0.554

High

206786

ESR1
Estrogen receptor

1

20

Small-scale

0.546

High

206787

S100B
Protein S100-B

1

7

High-throughput

0.536

High

206828

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.536

High

206864

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.536

High

206851

ERBIN
Erbin

1

5

Small-scale

0.527

High

206808

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

206859

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

13

Small-scale

0.515

High

206779

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

206784

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

206842

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.508

High

206818

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.481

High

206833

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

206856

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.480

High

162226

XPO1
Exportin-1

1

9

High-throughput

0.479

High

206781

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.479

High

206782

CHK2
Serine/threonine-protein kinase Chk2

1

13

Small-scale

0.479

High

206783

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

206785

MYC
Myc proto-oncogene protein

1

18

Small-scale

0.479

High

206791

IBP1
Insulin-like growth factor-binding protein 1

1

1

Small-scale

0.479

High

206793

PIM1
Serine/threonine-protein kinase pim-1

1

8

Small-scale

0.479

High

206795

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

206796

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

206798

PGFRA
Platelet-derived growth factor receptor alpha

1

5

Small-scale

0.479

High

206802

SHC1
SHC-transforming protein 1

1

7

Small-scale

0.479

High

206804

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

5

Small-scale

0.479

High

206811

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

206812

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.479

High

206813

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

7

Small-scale

0.479

High

206815

HCFC1
Host cell factor 1

1

6

Small-scale

0.479

High

206832

STK4
Serine/threonine-protein kinase 4

1

9

Small-scale

0.479

High

206836

CTBP1
C-terminal-binding protein 1

1

9

High-throughput

0.479

High

206841

SMAD1
Mothers against decapentaplegic homolog 1

1

18

Small-scale

0.479

High

206843

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

Small-scale

0.479

High

206844

SIR6
NAD-dependent protein deacylase sirtuin-6

1

13

Small-scale

0.479

High

206845

BICD2
Protein bicaudal D homolog 2

1

5

High-throughput

0.479

High

206854

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

206857

HIPK2
Homeodomain-interacting protein kinase 2

1

13

Small-scale

0.479

High

206858

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

206860

NLK
Serine/threonine-protein kinase NLK

1

9

Small-scale

0.479

High

206861

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

206865

HCFC2
Host cell factor 2

1

6

Small-scale

0.479

High

206814

ARRB1
Beta-arrestin-1

1

0

Small-scale

0.458

High

206855

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

206863

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

206792

ANDR
Androgen receptor

1

20

Small-scale

0.445

High

206810

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

206816

IMA1
Importin subunit alpha-1

1

3

Small-scale

0.445

High

206823

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.445

High

206839

IMB1
Importin subunit beta-1

1

7

Small-scale

0.445

High

206790

CFAH
Complement factor H

1

4

Small-scale

0.437

High


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Last updated: 15 Jul 2024