Interactor 1: FLCN (Q8NFG4)
Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein)
Gene: FLCN

Interactor 2: FNIP2 (Q9P278)
Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)
Gene: FNIP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.919

The method score is based on:

Property Details
Experiments 27353360, 28656962, 25126726, 33137092, 18403135
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FNIP_M~Folliculin, FNIP_N~Folliculin, FNIP_C~Folliculin_C
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:1904263 - positive regulation of TORC1 signaling
and 1 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 579
Hs

1 1114
+ Mm
+ Hs

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Last updated: 15 Jul 2024