HitPredict

Interactor 1: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Interactor 2: TCPW (Q92526)
T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303)
Gene: CCT6B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 731 Hs			1 530
+	Hs
		1246158 COP1_HUMAN (1-731): 0: 540: 100.00		TCPH_HUMAN (2-529): 0: 568: 27.43
+	Hs
		770940 COP1_HUMAN (1-731): 0: 540: 100.00		TCPZ_HUMAN (1-530): 0: 558: 85.85
+	Hs
		826781 COP1_HUMAN (1-731): 0: 540: 100.00		TCPG_HUMAN (3-527): 0: 551: 28.20
+	Hs
		821324 COP1_HUMAN (1-731): 0: 540: 100.00		TCPE_HUMAN (3-527): 0: 541: 30.34
+	Sc
		744619 TAF5_YEAST (96-683): 1.17e-82: 280: 14.26		TCPZ_YEAST (3-530): 0: 555: 54.53
+	Sc
		744637 TAF5_YEAST (96-683): 1.17e-82: 280: 14.26		TCPH_YEAST (4-527): 0: 533: 25.61
+	Sc
		744617 TAF5_YEAST (96-683): 1.17e-82: 280: 14.26		TCPG_YEAST (2-527): 0: 530: 27.64
+	Hs
		1240450 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		TCPH_HUMAN (2-529): 0: 568: 27.43
+	Hs
		770968 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		TCPZ_HUMAN (1-530): 0: 558: 85.85
+	Hs
		826807 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		TCPG_HUMAN (3-527): 0: 551: 28.20
+	Hs
		770932 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		TCPZ_HUMAN (1-530): 0: 558: 85.85
+	Sc
		761020 COPB2_YEAST (411-723): 4.62e-66: 236: 20.13		TCPZ_YEAST (3-530): 0: 555: 54.53
+	Hs
		826772 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		TCPG_HUMAN (3-527): 0: 551: 28.20
+	Hs
		821316 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		TCPE_HUMAN (3-527): 0: 541: 30.34
+	Hs
		770916 WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79		TCPZ_HUMAN (1-530): 0: 558: 85.85
+	Sc
		784372 COPB2_YEAST (411-723): 4.62e-66: 236: 20.13		TCPH_YEAST (4-527): 0: 533: 25.61
+	Hs
		573381 COP1_HUMAN (1-731): 0: 540: 100.00		TCPA_HUMAN (23-523): 2.19e-67: 228: 28.68
+	Hs
		573406 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		TCPA_HUMAN (23-523): 2.19e-67: 228: 28.68
+	Hs
		573371 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		TCPA_HUMAN (23-523): 2.19e-67: 228: 28.68
+	Hs
		573346 WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79		TCPA_HUMAN (23-523): 2.19e-67: 228: 28.68