HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	25723849, 22496338, 23644597, 23938591, 19343052
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 685
+	Hs
		476205 ITCH_HUMAN (1-870): 0: 902: 54.26		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476350 WWP1_HUMAN (1-870): 0: 888: 58.38		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476229 NED4L_HUMAN (5-867): 0: 785: 32.17		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475470 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475984 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		89879 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		UBIQP_DROME (1-610): 0: 752: 99.84
+	Hs
		125347 WWP2_HUMAN (1-870): 0: 982: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		125112 WWP2_HUMAN (1-870): 0: 982: 100.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		475140 ITCH_HUMAN (1-870): 0: 902: 54.26		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Rn
		1140970 Q5YB86_RAT (11-870): 0: 876: 55.68		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Sp
		143368 PTR1_SCHPO (411-868): 2.16e-163: 530: 34.86		UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80
+	Sc
		477424 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		397834 NEDD4_HUMAN (90-867): 0: 731: 35.94		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		474953 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	At
		1091758 UPL1_ARATH (359-868): 4.41e-172: 555: 33.40		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091762 UPL2_ARATH (374-868): 2.79e-170: 550: 33.91		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00
+	Mm
		476858 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475080 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70