HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25071155, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0045892 - negative regulation of DNA-templated transcription GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 245
+	Hs
		125318 WWP2_HUMAN (1-870): 0: 982: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		125351 WWP2_HUMAN (1-870): 0: 982: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		647191 ITCH_HUMAN (1-870): 0: 902: 54.26		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		125183 WWP2_HUMAN (1-870): 0: 982: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		647267 WWP1_HUMAN (1-870): 0: 888: 58.38		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		684266 ITCH_HUMAN (1-870): 0: 902: 54.26		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904987 ITCH_HUMAN (1-870): 0: 902: 54.26		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		909930 NED4L_HUMAN (5-867): 0: 785: 32.17		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Mm
		910302 NED4L_MOUSE (4-867): 0: 781: 31.91		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		647201 NED4L_HUMAN (5-867): 0: 785: 32.17		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		927423 NED4L_HUMAN (5-867): 0: 785: 32.17		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683637 NED4L_HUMAN (5-867): 0: 785: 32.17		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Mm
		1208289 NED4L_MOUSE (4-867): 0: 781: 31.91		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Hs
		646713 NEDD4_HUMAN (90-867): 0: 731: 35.94		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		683192 NEDD4_HUMAN (90-867): 0: 731: 35.94		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		684276 NED4L_HUMAN (5-867): 0: 785: 32.17		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		982400 NED4L_HUMAN (5-867): 0: 785: 32.17		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		905007 NED4L_HUMAN (5-867): 0: 785: 32.17		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		683894 NEDD4_HUMAN (90-867): 0: 731: 35.94		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		808076 NEDD4_HUMAN (90-867): 0: 731: 35.94		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33