HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: ARRD4 (Q8NCT1)
Arrestin domain-containing protein 4
Gene: ARRDC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	38270169, 23236378
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 418
+	Hs
		125633 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD3_HUMAN (15-413): 6.19e-140: 407: 51.35
+	Hs
		125595 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD2_HUMAN (16-405): 2.62e-123: 365: 46.19
+	Hs
		1241904 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD4_HUMAN (1-418): 3.79e-150: 433: 100.00
+	Hs
		125707 WWP2_HUMAN (1-870): 0: 982: 100.00		TXNIP_HUMAN (16-403): 6.64e-116: 345: 43.45
+	Hs
		1241917 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD4_HUMAN (1-418): 3.79e-150: 433: 100.00
+	Hs
		1285047 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD3_HUMAN (15-413): 6.19e-140: 407: 51.35
+	Hs
		1285070 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD3_HUMAN (15-413): 6.19e-140: 407: 51.35
+	Hs
		1252807 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD2_HUMAN (16-405): 2.62e-123: 365: 46.19
+	Hs
		1252814 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD2_HUMAN (16-405): 2.62e-123: 365: 46.19
+	Hs
		1294858 ITCH_HUMAN (1-870): 0: 902: 54.26		TXNIP_HUMAN (16-403): 6.64e-116: 345: 43.45
+	Hs
		1327911 WWP1_HUMAN (1-870): 0: 888: 58.38		TXNIP_HUMAN (16-403): 6.64e-116: 345: 43.45
+	Hs
		125580 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD1_HUMAN (15-405): 5.14e-66: 218: 23.86
+	Hs
		686035 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRB2_HUMAN (24-363): 9.37e-79: 250: 14.32
+	Hs
		827260 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRB1_HUMAN (24-339): 9.17e-78: 248: 14.40
+	Dm
		1367634 SUDX_DROME (14-870): 0: 852: 52.14		Q9VI00_DROME (18-415): 2.18e-96: 297: 23.94
+	Mm
		1208049 ITCH_MOUSE (1-870): 0: 892: 55.81		ARRB2_MOUSE (24-363): 1.54e-76: 245: 14.82
+	Hs
		1234600 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD1_HUMAN (15-405): 5.14e-66: 218: 23.86
+	Dm
		1367613 SUDX_DROME (14-870): 0: 852: 52.14		Q9VHZ7_DROME (20-320): 5.91e-81: 259: 25.33
+	Hs
		1234607 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD1_HUMAN (15-405): 5.14e-66: 218: 23.86
+	Dm
		1366476 SUDX_DROME (14-870): 0: 852: 52.14		Q9VGU4_DROME (19-313): 1.36e-61: 209: 20.13