HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SCNNB (P51168)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	12167593, 11244092
Identification Methods	pull down, far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 640
+	Hs
		845977 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNB_HUMAN (1-640): 0: 701: 100.00
+	Hs
		125257 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNG_HUMAN (17-626): 0: 580: 36.22
+	Hs
		125197 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Rn
		739630 Q4V8H7_RAT (1-870): 0: 902: 58.85		SCNNG_RAT (16-625): 0: 586: 36.16
+	Hs
		845978 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNB_HUMAN (1-640): 0: 701: 100.00
+	Hs
		739603 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Hs
		739608 WWP1_HUMAN (1-870): 0: 888: 58.38		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Mm
		1208291 NED4L_MOUSE (4-867): 0: 781: 31.91		SCNNB_MOUSE (1-640): 0: 664: 83.91
+	Hs
		808049 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNB_HUMAN (1-640): 0: 701: 100.00
+	Hs
		845991 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNG_HUMAN (17-626): 0: 580: 36.22
+	Mm
		93285 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNB_MOUSE (1-640): 0: 664: 83.91
+	Hs
		739604 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Hs
		808050 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNG_HUMAN (17-626): 0: 580: 36.22
+	Hs
		739582 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Mm
		93286 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNG_MOUSE (16-625): 0: 587: 36.19
+	Mm
		93272 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNA_MOUSE (21-639): 0: 556: 31.01
+	Hs
		739597 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		SCNNA_HUMAN (21-627): 0: 558: 31.54
+	Rn
		739628 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNB_RAT (1-640): 0: 683: 83.44
+	Rn
		739631 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNG_RAT (16-625): 0: 586: 36.16
+	Rn
		739625 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNA_RAT (21-640): 0: 554: 30.81