HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SCNNG (P51170)
Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
Gene: SCNN1G

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12167593
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 649
+	Rn
		739630 Q4V8H7_RAT (1-870): 0: 902: 58.85		SCNNG_RAT (1-649): 0: 755: 86.62
+	Hs
		125256 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		125197 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		845991 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNG_HUMAN (1-649): 0: 770: 100.00
+	Hs
		845977 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		808050 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNG_HUMAN (1-649): 0: 770: 100.00
+	Hs
		739603 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		739608 WWP1_HUMAN (1-870): 0: 888: 58.38		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Mm
		93286 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNG_MOUSE (1-649): 0: 739: 85.50
+	Hs
		845978 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739604 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Mm
		1208291 NED4L_MOUSE (4-867): 0: 781: 31.91		SCNNB_MOUSE (24-633): 0: 577: 35.27
+	Hs
		808049 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739582 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Mm
		93272 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNA_MOUSE (24-611): 0: 579: 33.05
+	Mm
		93285 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNB_MOUSE (24-633): 0: 577: 35.27
+	Hs
		739597 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Rn
		739631 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNG_RAT (1-649): 0: 755: 86.62
+	Rn
		739628 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNB_RAT (24-633): 0: 593: 36.07
+	Rn
		739625 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNA_RAT (24-611): 0: 578: 33.39