HitPredict

Interactor 1: KDM1A (Q6ZQ88)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)
Gene: KDM1A

Interactor 2: RCOR2 (Q8C796)
REST corepressor 2 (M-CoREST)
Gene: RCOR2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	26206133, 27112428, 34709266
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Amino_oxidase~Myb_DNA-binding, Amino_oxidase~REST_helical
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0019899 - enzyme binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 853 Mm			1 523
+	Hs
		246748 KDM1A_HUMAN (1-853): 0: 1019: 98.12		RCOR2_HUMAN (1-523): 2.26e-146: 432: 97.51
+	Hs
		247001 KDM1A_HUMAN (1-853): 0: 1019: 98.12		RCOR3_HUMAN (46-520): 1.38e-129: 388: 57.81
+	Hs
		247019 KDM1A_HUMAN (1-853): 0: 1019: 98.12		RCOR1_HUMAN (15-425): 4.75e-113: 345: 52.04
+	Hs
		246909 KDM1A_HUMAN (1-853): 0: 1019: 98.12		MTA3_HUMAN (24-470): 3.07e-105: 328: 15.57
+	Mm
		1253493 KDM1A_MOUSE (1-853): 0: 998: 100.00		RCOR1_MOUSE (15-428): 9.04e-111: 339: 51.65
+	Hs
		246356 KDM1A_HUMAN (1-853): 0: 1019: 98.12		MTA2_HUMAN (5-514): 2.78e-93: 300: 18.01
+	Hs
		246575 KDM1A_HUMAN (1-853): 0: 1019: 98.12		MTA1_HUMAN (24-471): 1.17e-89: 291: 15.31
+	Mm
		1253518 KDM1A_MOUSE (1-853): 0: 998: 100.00		MTA3_MOUSE (24-480): 1.86e-95: 303: 16.06
+	Mm
		1244290 KDM1A_MOUSE (1-853): 0: 998: 100.00		RCOR3_MOUSE (1-483): 4.53e-87: 277: 42.52
+	Hs
		246340 KDM1A_HUMAN (1-853): 0: 1019: 98.12		NCOR1_HUMAN (81-522): 2.37e-63: 226: 15.84
+	Mm
		1253461 KDM1A_MOUSE (1-853): 0: 998: 100.00		RERE_MOUSE (8-520): 1.52e-53: 197: 14.89
+	Mm
		1253483 KDM1A_MOUSE (1-853): 0: 998: 100.00		TREF1_MOUSE (19-357): 8.18e-50: 186: 19.78
+	Mm
		1253550 KDM1A_MOUSE (1-853): 0: 998: 100.00		NCOR2_MOUSE (131-520): 5.19e-09: 61.2: 13.22
+	Dm
		1202437 LSDA_DROME (36-845): 0: 836: 50.82		RCOR_DROME (7-512): 1.47e-53: 192: 25.23
+	Ce
		1166333 KDM1A_CAEEL (183-832): 1e-177: 533: 27.60		RCORB_CAEEL (38-376): 7.43e-67: 227: 15.56
+	Ce
		1378744 KDM1A_CAEEL (183-832): 1e-177: 533: 27.60		RCORA_CAEEL (36-189): 3.42e-49: 179: 24.68