HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25071155, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 126
+	Hs
		125676 WWP2_HUMAN (1-870): 0: 982: 100.00		H2B1N_HUMAN (1-126): 3.35e-53: 164: 98.41
+	Hs
		1087225 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918477 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241572 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		886146 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1192122 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Sc
		355609 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1087416 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00