Protein: ICOSL
ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)

Gene: ICOSL, ICOSLG
Organism: Homo sapiens
Interactions: 20
UniProt ID: O75144

Gene Ontology (top 5):
GO:0001817 - regulation of cytokine production
GO:0002250 - adaptive immune response
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0006952 - defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

271606

ICOS
Inducible T-cell costimulator

3

1

Small-scale

0.880

High

155424

C2C2L
Phospholipid transfer protein C2CD2L

2

1

High-throughput

0.811

High

271593

LEG1
Galectin-1

2

12

High-throughput

0.811

High

271594

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

9

High-throughput

0.811

High

271603

SEC12
Guanine nucleotide-exchange factor SEC12

2

2

High-throughput

0.811

High

271592

ICOSL
ICOS ligand

1

16

Small-scale

0.761

High

271595

UFO
Tyrosine-protein kinase receptor UFO

1

19

High-throughput

0.691

High

271601

PDZD8
PDZ domain-containing protein 8

1

3

High-throughput

0.691

High

271596

CLCN3
H(+)/Cl(-) exchange transporter 3

1

0

High-throughput

0.656

High

72649

UPK3L
Uroplakin-3b-like protein 1

2

1

High-throughput

0.628

High

61067

T131L
Transmembrane protein 131-like

1

3

High-throughput

0.536

High

271599

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.536

High

271604

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

2

High-throughput

0.536

High

271605

AMFR
E3 ubiquitin-protein ligase AMFR

1

6

High-throughput

0.536

High

271598

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.513

High

231425

ORC4
Origin recognition complex subunit 4

1

4

High-throughput

0.489

High

271602

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.489

High

271597

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.279

Low

271600

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025