Protein: INSI2
Insulin-induced gene 2 protein (INSIG-2)

Gene: INSI2, INSIG2
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q9Y5U4

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006641 - triglyceride metabolic process
GO:0006695 - cholesterol biosynthetic process
GO:0008142 - oxysterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1016052

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

4

3

Small-scale

0.867

High

1307276

RNF5
E3 ubiquitin-protein ligase RNF5

3

2

High-throughput

0.675

High

1378117

INSI2
Insulin-induced gene 2 protein

1

2

Small-scale

0.647

High

181131

INSI1
Insulin-induced gene 1 protein

1

2

Small-scale

0.618

High

373169

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

3

Small-scale

0.618

High

750688

INGR2
Interferon gamma receptor 2

2

1

High-throughput

0.606

High

502731

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.584

High

1356618

AMFR
E3 ubiquitin-protein ligase AMFR

2

5

Small-scale

0.584

High

1039527

LAPM5
Lysosomal-associated transmembrane protein 5

2

0

High-throughput

0.580

High

1040313

STIM1
Stromal interaction molecule 1

2

0

High-throughput

0.580

High

1068392

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1114080

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.580

High

1191234

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1234010

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1252029

ABHD4
(Lyso)-N-acylphosphatidylethanolamine lipase

2

0

High-throughput

0.580

High

1285303

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

1309355

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.580

High

1377515

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

724475

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.578

High

875485

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.561

High

545189

PVR
Poliovirus receptor

2

2

High-throughput

0.553

High

781314

AQP2
Aquaporin-2

2

2

High-throughput

0.553

High

1037779

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

1300172

TM237
Transmembrane protein 237

2

1

High-throughput

0.553

High

505019

HSP7C
Heat shock cognate 71 kDa protein

2

2

Small-scale

0.533

High

907205

PRS8
26S proteasome regulatory subunit 8

1

2

Small-scale

0.512

High

302455

CSTN1
Calsyntenin-1

1

1

High-throughput

0.479

High

315788

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.479

High

373089

VTNC
Vitronectin

1

1

High-throughput

0.479

High

434680

TSP1
Thrombospondin-1

1

1

High-throughput

0.479

High

439890

INHBA
Inhibin beta A chain

1

1

High-throughput

0.479

High

654937

CALX
Calnexin

1

1

High-throughput

0.479

High

725620

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.479

High

739002

SRBP1
Sterol regulatory element-binding protein 1

1

3

Small-scale

0.479

High

800115

VDAC2
Voltage-dependent anion-selective channel protein 2

1

1

High-throughput

0.479

High

863613

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

931507

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

1074032

SC23A
Protein transport protein Sec23A

1

1

High-throughput

0.479

High

1079870

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.479

High

1259711

RN139
E3 ubiquitin-protein ligase RNF139

1

5

Small-scale

0.479

High

1268549

PXDN
Peroxidasin homolog

1

1

High-throughput

0.479

High

1287236

FAF2
FAS-associated factor 2

1

1

Small-scale

0.479

High

1298015

RN145
RING finger protein 145

1

5

Small-scale

0.479

High

1357353

UBQL1
Ubiquilin-1

1

2

Small-scale

0.479

High

868068

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.460

High

1326314

ELOV4
Very long chain fatty acid elongase 4

1

0

High-throughput

0.460

High

1377092

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.460

High

149789

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

390643

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

616605

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

819052

COPD
Coatomer subunit delta

1

0

High-throughput

0.458

High

1184676

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.458

High

156386

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.457

High

573124

PRS6A
26S proteasome regulatory subunit 6A

1

4

Small-scale

0.457

High

594672

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.457

High

360586

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

121885

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

Small-scale

0.437

High

122114

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

Small-scale

0.437

High

153840

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.437

High

211701

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

299091

PHF14
PHD finger protein 14

1

1

High-throughput

0.437

High

364495

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

409289

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.437

High

419090

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.437

High

427706

ANXA2
Annexin A2

1

1

High-throughput

0.437

High

430503

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.437

High

433210

LAMB1
Laminin subunit beta-1

1

3

High-throughput

0.437

High

438656

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

453737

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.437

High

500253

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.437

High

531440

K1C10
Keratin, type I cytoskeletal 10

1

3

High-throughput

0.437

High

531649

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.437

High

533362

PLST
Plastin-3

1

3

High-throughput

0.437

High

554826

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

564215

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.437

High

585102

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.437

High

598395

FLNA
Filamin-A

1

6

High-throughput

0.437

High

610129

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

631270

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

637764

PSA2
Proteasome subunit alpha type-2

1

3

Small-scale

0.437

High

638225

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.437

High

664395

CCN2
CCN family member 2

1

2

High-throughput

0.437

High

685147

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

714478

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.437

High

729201

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

High-throughput

0.437

High

730396

PRS7
26S proteasome regulatory subunit 7

1

2

Small-scale

0.437

High

751900

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.437

High

796819

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.437

High

803829

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.437

High

826101

FAS
Fatty acid synthase

1

1

High-throughput

0.437

High

830513

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.437

High

832069

PSB3
Proteasome subunit beta type-3

1

2

Small-scale

0.437

High

904207

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.437

High

913379

PRS10
26S proteasome regulatory subunit 10B

1

2

Small-scale

0.437

High

929748

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.437

High

930068

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.437

High

932934

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.437

High

933687

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.437

High

965465

K22O
Keratin, type II cytoskeletal 2 oral

1

6

High-throughput

0.437

High

989425

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.437

High

1117723

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.437

High

1129957

PPR29
Protein phosphatase 1 regulatory subunit 29

1

1

High-throughput

0.437

High

1138831

CCD30
Coiled-coil domain-containing protein 30

1

1

High-throughput

0.437

High

1148295

ZN772
Zinc finger protein 772

1

1

High-throughput

0.437

High

1175324

H2AV
Histone H2A.V

1

1

High-throughput

0.437

High

1199725

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1202220

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.437

High

1242174

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.437

High

1262682

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.437

High

1309547

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.437

High

1355424

UBQL2
Ubiquilin-2

1

2

Small-scale

0.437

High

1357587

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.437

High

1377054

RUVB1
RuvB-like 1

1

1

High-throughput

0.437

High

1378118

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

147122

NEMP1
Nuclear envelope integral membrane protein 1

2

0

High-throughput

0.316

High

243216

G37L1
G-protein coupled receptor 37-like 1

2

0

High-throughput

0.316

High

516180

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

554386

MUC1
Mucin-1

2

0

High-throughput

0.316

High

560482

PRLR
Prolactin receptor

2

0

High-throughput

0.316

High

639670

TNR5
Tumor necrosis factor receptor superfamily member 5

2

0

High-throughput

0.316

High

798228

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

0

High-throughput

0.316

High

816672

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

1031812

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1117410

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.316

High

1128756

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1192800

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

1239887

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1251308

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

1255451

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

1256226

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1257297

MOT10
Monocarboxylate transporter 10

2

0

High-throughput

0.316

High

1284920

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

1303509

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

0

High-throughput

0.316

High

1345975

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1348257

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.316

High

1303213

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.269

Low

1060738

NTCP
Hepatic sodium/bile acid cotransporter

1

0

High-throughput

0.251

Low

1110134

AR13B
ADP-ribosylation factor-like protein 13B

1

0

High-throughput

0.251

Low

1296531

F210B
Protein FAM210B, mitochondrial

1

0

High-throughput

0.251

Low

1329526

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.251

Low

1343538

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.251

Low

60173

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.249

Low

131123

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

Small-scale

0.249

Low

254849

ASTN2
Astrotactin-2

1

0

High-throughput

0.249

Low

273504

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.249

Low

382193

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.249

Low

417461

ENOA
Alpha-enolase

1

0

Small-scale

0.249

Low

518806

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.249

Low

542488

PLAK
Junction plakoglobin

1

0

Small-scale

0.249

Low

551880

DESP
Desmoplakin

1

0

Small-scale

0.249

Low

610942

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.249

Low

637102

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

794199

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

815061

LEG7
Galectin-7

1

0

Small-scale

0.249

Low

874207

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low

910977

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

974034

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.249

Low

1057878

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

1081054

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.249

Low

1161259

TM10B
tRNA methyltransferase 10 homolog B

1

0

High-throughput

0.249

Low

1164828

AFTIN
Aftiphilin

1

0

High-throughput

0.249

Low

1201221

THOC4
THO complex subunit 4

1

0

High-throughput

0.249

Low

1229932

TAGAP
T-cell activation Rho GTPase-activating protein

1

0

High-throughput

0.249

Low

1245050

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.249

Low

1302658

MA7D2
MAP7 domain-containing protein 2

1

0

High-throughput

0.249

Low

1303504

PSB7
Proteasome subunit beta type-7

1

0

High-throughput

0.249

Low

1305329

PHB2
Prohibitin-2

1

0

High-throughput

0.249

Low

1328948

EPN3
Epsin-3

1

0

High-throughput

0.249

Low

1329004

S1PR5
Sphingosine 1-phosphate receptor 5

1

0

High-throughput

0.249

Low

1349971

BTBD7
BTB/POZ domain-containing protein 7

1

0

High-throughput

0.249

Low

1357547

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

Small-scale

0.249

Low

1377008

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.249

Low

1377538

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024