HitPredict

Interactor 1: ES8L1 (Q8TE68)
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)
Gene: EPS8L1

Interactor 2: BAIP2 (Q9UQB8)
BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
Gene: BAIAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 723 Hs			1 552
+	Rn
		88583 D3ZDV2_RAT (5-723): 0: 805: 82.50		BAIP2_RAT (1-529): 1.31e-130: 393: 94.72
+	Hs
		1020413 EPS8_HUMAN (3-716): 0: 754: 34.96		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Mm
		995947 EPS8_MOUSE (3-716): 0: 753: 35.60		BAIP2_MOUSE (1-529): 6.33e-131: 394: 95.09
+	Hs
		1020408 EPS8_HUMAN (3-716): 0: 754: 34.96		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Hs
		1020402 EPS8_HUMAN (3-716): 0: 754: 34.96		ITSN2_HUMAN (166-444): 7.54e-12: 70.6: 14.13
+	Hs
		434085 LYN_HUMAN (451-704): 2.54e-55: 199: 15.89		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		209189 NCK2_HUMAN (478-605): 1.59e-36: 143: 23.70		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		557833 NCK1_HUMAN (478-605): 5.2e-32: 130: 22.96		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		434060 LYN_HUMAN (451-704): 2.54e-55: 199: 15.89		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Hs
		433732 LYN_HUMAN (451-704): 2.54e-55: 199: 15.89		MYO1E_HUMAN (7-435): 3.08e-57: 208: 13.65
+	Hs
		411715 LCK_HUMAN (417-701): 3.51e-67: 232: 15.36		SPTN1_HUMAN (3-442): 2.09e-42: 165: 11.85
+	Hs
		433753 LYN_HUMAN (451-704): 2.54e-55: 199: 15.89		SPTN1_HUMAN (3-442): 2.09e-42: 165: 11.85
+	Hs
		433354 YES_HUMAN (423-704): 9.94e-57: 204: 12.58		LASP1_HUMAN (207-435): 2.59e-40: 148: 15.98
+	Hs
		433781 LYN_HUMAN (451-704): 2.54e-55: 199: 15.89		ITSN1_HUMAN (268-455): 5.42e-10: 64.5: 15.18