HitPredict

Interactor 1: RB27B (O00194)
Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG)
Gene: RAB27B

Interactor 2: SYTL4 (Q96C24)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	28514442, 11956164, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0045921 - positive regulation of exocytosis GO:0070382 - exocytic vesicle GO:0071985 - multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 671
+	Hs
		630433 RAB3A_HUMAN (2-218): 2.42e-91: 268: 39.63		SYTL4_HUMAN (1-671): 0: 591: 100.00
+	Hs
		343187 RAB3D_HUMAN (2-218): 5.53e-90: 265: 41.48		SYTL4_HUMAN (1-671): 0: 591: 100.00
+	Mm
		989215 RAB3A_MOUSE (2-218): 9.26e-92: 269: 39.63		SYTL4_MOUSE (1-671): 0: 566: 90.19
+	Mm
		1408946 RB27B_MOUSE (1-218): 1.36e-86: 256: 94.50		SYTL4_MOUSE (1-671): 0: 566: 90.19
+	Mm
		937173 RAB8A_MOUSE (1-217): 5.16e-85: 252: 38.25		SYTL4_MOUSE (1-671): 0: 566: 90.19
+	Hs
		630431 RAB3A_HUMAN (2-218): 2.42e-91: 268: 39.63		SYTL5_HUMAN (2-669): 1.9e-160: 480: 38.30
+	Hs
		126000 RB27B_HUMAN (1-218): 8.97e-88: 259: 100.00		SYTL5_HUMAN (2-669): 1.9e-160: 480: 38.30
+	Hs
		125994 RB27B_HUMAN (1-218): 8.97e-88: 259: 100.00		SYTL3_HUMAN (1-660): 8.59e-127: 390: 30.19
+	Hs
		126009 RB27B_HUMAN (1-218): 8.97e-88: 259: 100.00		SYTL2_HUMAN (123-664): 5.76e-94: 312: 33.15
+	Hs
		125997 RB27B_HUMAN (1-218): 8.97e-88: 259: 100.00		SYTL1_HUMAN (110-665): 3.43e-85: 280: 29.44
+	Mm
		866414 RAB3A_MOUSE (2-218): 9.26e-92: 269: 39.63		RP3A_MOUSE (519-671): 6.33e-29: 124: 22.62
+	Rn
		866423 RAB3A_RAT (2-218): 9.26e-92: 269: 39.63		RP3A_RAT (508-671): 9.73e-29: 123: 21.79
+	Hs
		630450 RAB3A_HUMAN (2-218): 2.42e-91: 268: 39.63		RP3A_HUMAN (519-671): 1.21e-28: 123: 23.21
+	Mm
		866413 RAB3C_MOUSE (2-218): 1.16e-89: 264: 39.91		RP3A_MOUSE (519-671): 6.33e-29: 124: 22.62
+	Hs
		126013 RB27B_HUMAN (1-218): 8.97e-88: 259: 100.00		RP3A_HUMAN (519-671): 1.21e-28: 123: 23.21
+	Mm
		866419 RB27B_MOUSE (1-218): 1.36e-86: 256: 94.50		RP3A_MOUSE (519-671): 6.33e-29: 124: 22.62
+	Mm
		866412 RAB8A_MOUSE (1-217): 5.16e-85: 252: 38.25		RP3A_MOUSE (519-671): 6.33e-29: 124: 22.62
+	Mm
		989206 RAB3A_MOUSE (2-218): 9.26e-92: 269: 39.63		RIMS1_MOUSE (132-648): 2.24e-17: 88.9: 13.87
+	Mm
		981437 RAB3C_MOUSE (2-218): 1.16e-89: 264: 39.91		RIMS1_MOUSE (132-648): 2.24e-17: 88.9: 13.87
+	Hs
		136168 RAB1A_HUMAN (1-217): 6.22e-85: 252: 35.62		SYT5_HUMAN (347-458): 3.14e-19: 92.2: 31.25