HitPredict

Interactor 1: TM171 (Q8WVE6)
Transmembrane protein 171
Gene: TMEM171

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 324 Hs			1 903
+	Hs
		1261332 TM171_HUMAN (1-324): 0: 669: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808204 TM171_HUMAN (1-324): 0: 669: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1261346 TM171_HUMAN (1-324): 0: 669: 100.00		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		1176341 TM171_HUMAN (1-324): 0: 669: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76