Protein: DDX49
Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49)

Gene: DDX49
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9Y6V7

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1412778

FEM1A
Protein fem-1 homolog A

1

5

High-throughput

0.618

High

1414640

DDX23
Probable ATP-dependent RNA helicase DDX23

1

17

High-throughput

0.618

High

1461818

ABT1
Activator of basal transcription 1

2

6

High-throughput

0.601

High

243458

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.584

High

373658

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.584

High

981210

H2B1C
Histone H2B type 1-C/E/F/G/I

2

12

High-throughput

0.584

High

1252093

RN19B
E3 ubiquitin-protein ligase RNF19B

2

19

High-throughput

0.574

High

1460152

EVL
Ena/VASP-like protein

2

1

High-throughput

0.574

High

397351

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1159663

STX1A
Syntaxin-1A

2

1

High-throughput

0.553

High

1256327

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.553

High

928244

HAP1
Huntingtin-associated protein 1

1

2

High-throughput

0.541

High

634719

LMNB1
Lamin-B1

1

15

High-throughput

0.536

High

733280

OTX2
Homeobox protein OTX2

1

4

High-throughput

0.536

High

1335968

ZBT44
Zinc finger and BTB domain-containing protein 44

1

6

High-throughput

0.536

High

1341266

CTCFL
Transcriptional repressor CTCFL

1

6

High-throughput

0.536

High

887751

PSB2
Proteasome subunit beta type-2

1

0

High-throughput

0.518

High

141194

NOP56
Nucleolar protein 56

1

8

High-throughput

0.479

High

158048

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

191188

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

320200

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

463877

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

485548

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

13

High-throughput

0.479

High

487946

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

558527

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

590169

RFA2
Replication protein A 32 kDa subunit

1

11

High-throughput

0.479

High

697006

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

697313

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

769655

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

883751

CENPA
Histone H3-like centromeric protein A

1

17

High-throughput

0.479

High

905358

MECP2
Methyl-CpG-binding protein 2

1

13

High-throughput

0.479

High

938006

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

979389

RS6
Small ribosomal subunit protein eS6

1

8

High-throughput

0.479

High

982900

RS24
Small ribosomal subunit protein eS24

1

5

High-throughput

0.479

High

985103

RL31
Large ribosomal subunit protein eL31

1

10

High-throughput

0.479

High

1040964

MECOM
Histone-lysine N-methyltransferase MECOM

1

7

High-throughput

0.479

High

1367726

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1393891

DDRGK
DDRGK domain-containing protein 1

1

7

High-throughput

0.479

High

1411784

RIOK1
Serine/threonine-protein kinase RIO1

1

10

High-throughput

0.479

High

1418663

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

18

High-throughput

0.479

High

1437894

PRD16
Histone-lysine N-methyltransferase PRDM16

1

7

High-throughput

0.479

High

1446471

BRD7
Bromodomain-containing protein 7

1

18

High-throughput

0.479

High

1454389

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

8

High-throughput

0.479

High

1459513

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1491284

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1337441

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.458

High

423559

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.457

High

430574

JUN
Transcription factor Jun

1

15

High-throughput

0.445

High

516376

CALM1
Calmodulin-1

1

4

High-throughput

0.445

High

516457

CALM2
Calmodulin-2

1

4

High-throughput

0.445

High

516611

CALM3
Calmodulin-3

1

4

High-throughput

0.445

High

951931

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

High-throughput

0.445

High

1132477

CASP8
Caspase-8

1

4

High-throughput

0.445

High

1327311

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1358154

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

1434384

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.437

High

397989

ANGI
Angiogenin

1

0

High-throughput

0.426

High

887396

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.408

High

1340208

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.407

High

282547

PAGE1
P antigen family member 1

3

0

High-throughput

0.346

High

1256473

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025