HitPredict

Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Interactor 2: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.806

The method score is based on:

Property Details
Experiments 9113989, 19380743
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~PI3_PI4_kinase, PI3_PI4_kinase~SH2, PI3K_C2~PI3K_P85_iSH2, PI3K_C2~SH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3Ka~SH2
Common GO terms GO:0005829 - cytosol
GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0005943 - phosphatidylinositol 3-kinase complex, class IA
GO:0006955 - immune response
GO:0030183 - B cell differentiation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1044
Hs

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Last updated: 15 Jul 2024