HitPredict

Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1044 Hs			1 304
+	Mm
		1144838 PK3CB_MOUSE (1-1043): 0: 1107: 55.95		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		126189 PK3CD_HUMAN (1-1044): 0: 1252: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		787357 PK3CB_HUMAN (1-1043): 0: 1080: 56.33		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		787358 PK3CB_HUMAN (1-1043): 0: 1080: 56.33		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		787184 PK3CA_HUMAN (1-1041): 0: 1016: 39.26		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		787344 PK3CA_MOUSE (1-1041): 0: 1019: 39.54		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		787365 PK3CB_HUMAN (1-1043): 0: 1080: 56.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		580952 PK3CA_HUMAN (1-1041): 0: 1016: 39.26		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		787202 PK3CA_HUMAN (1-1041): 0: 1016: 39.26		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Dm
		954617 P91634_DROME (9-1044): 0: 966: 38.76		Q9VXH3_DROME (8-212): 8.83e-22: 97.7: 19.83
+	Hs
		135771 P3C2B_HUMAN (78-1040): 0: 822: 26.74		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		135775 P3C2B_HUMAN (78-1040): 0: 822: 26.74		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		135796 P3C2B_HUMAN (78-1040): 0: 822: 26.74		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		135763 P3C2B_HUMAN (78-1040): 0: 822: 26.74		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		135781 P3C2B_HUMAN (78-1040): 0: 822: 26.74		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Mm
		93763 E9QAN8_MOUSE (102-1040): 0: 808: 26.82		ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98
+	Dm
		993186 Q7JNX6_DROME (219-1040): 0: 676: 27.99		GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43
+	Hs
		924472 PRKDC_HUMAN (488-993): 2.58e-95: 335: 18.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67