HitPredict

Interactor 1: LPAR1 (Q92633)
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
Gene: LPAR1

Interactor 2: GPC5B (Q9NZH0)
G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2)
Gene: GPRC5B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004930 - G protein-coupled receptor activity GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 403
+	Hs
		429139 ADRB2_HUMAN (54-350): 1.7e-66: 217: 17.38		GPC5B_HUMAN (1-403): 3.08e-124: 366: 100.00
+	Rn
		674774 AA2AR_RAT (48-351): 4.45e-66: 216: 21.98		GRM5_RAT (30-403): 7.17e-90: 296: 17.16
+	Hs
		723036 OPRM_HUMAN (2-363): 3.19e-67: 219: 15.28		GRM1_HUMAN (30-386): 3.65e-85: 283: 18.30
+	Hs
		664337 AA2AR_HUMAN (51-350): 2.67e-61: 204: 21.81		GRM5_HUMAN (30-403): 1.88e-89: 295: 16.91
+	Hs
		1268662 LPAR1_HUMAN (1-364): 3.44e-73: 233: 100.00		GPC5C_HUMAN (9-384): 1.11e-79: 253: 40.61
+	Hs
		664377 AA2BR_HUMAN (45-327): 9.42e-70: 223: 23.45		GPC5C_HUMAN (9-384): 1.11e-79: 253: 40.61
+	Hs
		1335592 LPAR2_HUMAN (23-364): 1.03e-59: 197: 53.06		GPC5C_HUMAN (9-384): 1.11e-79: 253: 40.61
+	Hs
		674767 AA1R_HUMAN (53-325): 1.32e-18: 87.4: 27.70		GRM1_HUMAN (30-386): 3.65e-85: 283: 18.30