Protein: S23IP
SEC23-interacting protein (p125)

Gene: S23IP, SEC23IP
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9Y6Y8

Gene Ontology (top 5):
GO:0004620 - phospholipase activity
GO:0003723 - RNA binding
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

318221

DDHD2
Triacylglycerol hydrolase DDHD2

3

1

High-throughput

0.861

High

1420087

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.691

High

51375

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

3

2

High-throughput

0.675

High

412915

NTRK1
High affinity nerve growth factor receptor

2

19

High-throughput

0.675

High

1462028

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.675

High

1093457

TRI32
E3 ubiquitin-protein ligase TRIM32

3

2

High-throughput

0.667

High

323926

SC31A
Protein transport protein Sec31A

3

6

Small-scale

0.667

High

1148973

SC23A
Protein transport protein Sec23A

3

10

High-throughput

0.665

High

1453201

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.624

High

170459

AURKA
Aurora kinase A

1

2

High-throughput

0.618

High

179649

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

18

High-throughput

0.618

High

541792

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

648761

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

777813

VGFR3
Vascular endothelial growth factor receptor 3

1

10

High-throughput

0.618

High

1107392

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.618

High

1157130

NTRK3
NT-3 growth factor receptor

1

18

High-throughput

0.618

High

276544

PDCD6
Programmed cell death protein 6

2

4

Small-scale

0.611

High

1396954

ANM6
Protein arginine N-methyltransferase 6

3

5

High-throughput

0.609

High

325629

YIF1A
Protein YIF1A

2

1

High-throughput

0.606

High

1149048

SC23B
Protein transport protein Sec23B

2

10

High-throughput

0.601

High

343125

HERC2
E3 ubiquitin-protein ligase HERC2

2

8

Small-scale

0.584

High

481426

HMGB1
High mobility group protein B1

2

6

High-throughput

0.584

High

976714

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

1063739

GOGA2
Golgin subfamily A member 2

2

7

High-throughput

0.584

High

838958

RHG25
Rho GTPase-activating protein 25

2

2

High-throughput

0.558

High

464095

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.553

High

710601

EPHA2
Ephrin type-A receptor 2

1

7

High-throughput

0.553

High

710781

EPHA8
Ephrin type-A receptor 8

1

9

High-throughput

0.553

High

289378

CTAG2
Cancer/testis antigen 2

2

1

High-throughput

0.549

High

1491488

IFT25
Intraflagellar transport protein 25 homolog

1

0

High-throughput

0.549

High

652446

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

938309

SEC13
Protein SEC13 homolog

1

8

High-throughput

0.536

High

1006328

CTG1B
Cancer/testis antigen 1

1

1

High-throughput

0.536

High

1399672

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

2

High-throughput

0.536

High

1123559

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

376656

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

1034859

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1402879

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.513

High

1179045

S35G1
Solute carrier family 35 member G1

1

4

High-throughput

0.489

High

1407026

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

125688

LEG9
Galectin-9

1

2

High-throughput

0.479

High

173629

XPO1
Exportin-1

1

8

High-throughput

0.479

High

180127

BET1
BET1 homolog

1

2

High-throughput

0.479

High

219045

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

243461

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

291611

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

323632

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.479

High

327528

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

374320

RASN
GTPase NRas

1

6

High-throughput

0.479

High

404583

GCR
Glucocorticoid receptor

1

15

High-throughput

0.479

High

560574

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

581409

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

604303

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

607287

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

630685

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

631605

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.479

High

687325

HMGB2
High mobility group protein B2

1

6

High-throughput

0.479

High

700770

PSA5
Proteasome subunit alpha type-5

1

1

Small-scale

0.479

High

715875

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

731753

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

799624

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

831742

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

895189

EMD
Emerin

1

1

High-throughput

0.479

High

901127

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.479

High

902179

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

910280

RND2
Rho-related GTP-binding protein RhoN

1

15

High-throughput

0.479

High

951557

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

955814

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.479

High

962695

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

968061

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

High-throughput

0.479

High

1015957

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1027255

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1041403

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1110233

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1121392

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

1199061

KLH12
Kelch-like protein 12

1

1

Small-scale

0.479

High

1226347

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.479

High

1256333

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1287487

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1289762

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1324127

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

1335132

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1360858

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.479

High

1367732

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1381565

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

1401745

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

3

High-throughput

0.479

High

1410923

GORS1
Golgi reassembly-stacking protein 1

1

1

High-throughput

0.479

High

1414523

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1429041

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

1430238

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

Small-scale

0.479

High

1434385

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1436380

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1447931

SAR1A
Small COPII coat GTPase SAR1A

1

8

High-throughput

0.479

High

1452747

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1453079

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

1454883

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1458454

RBL2A
Rab-like protein 2A

1

6

High-throughput

0.479

High

1459518

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1462803

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

1491828

SAR1B
Small COPII coat GTPase SAR1B

1

7

High-throughput

0.479

High

1490723

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.470

High

184346

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

437410

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

548390

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

847767

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1095332

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

1178496

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1339259

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1352419

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

1352909

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

1363919

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1365407

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1397137

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1407507

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1448056

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1453941

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

303303

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.445

High

1239581

ZNT6
Zinc transporter 6

1

1

High-throughput

0.445

High

1315734

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

1399246

PCFT
Proton-coupled folate transporter

1

1

High-throughput

0.445

High

1416740

OSB11
Oxysterol-binding protein-related protein 11

1

4

High-throughput

0.445

High

1419406

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

6

Small-scale

0.445

High

1449946

DDX28
Probable ATP-dependent RNA helicase DDX28

1

6

High-throughput

0.445

High

140050

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

189048

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.437

High

247061

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

590171

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

631054

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.437

High

643175

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

697008

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

769657

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1031630

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

1229150

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1233629

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1249383

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1293233

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1323070

CXD3
Gap junction delta-3 protein

1

4

High-throughput

0.437

High

1384494

PF21A
PHD finger protein 21A

1

5

High-throughput

0.437

High

1431812

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1404982

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

85427

B7ZBD5
RAB, member of RAS oncogene family like 2A

1

1

High-throughput

0.407

High

330391

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

870341

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.407

High

1104182

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1219566

ANR22
Ankyrin repeat domain-containing protein 22

1

2

High-throughput

0.407

High

1398034

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

190535

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

692481

G0S2
G0/G1 switch protein 2

1

0

High-throughput

0.279

Low

1211474

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1248602

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

1277751

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.279

Low

1358235

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1429702

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.279

Low

1491710

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.279

Low

1382993

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

947088

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

1490695

SL9A8
Sodium/hydrogen exchanger 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025