HitPredict

Interactor 1: RREB1 (Q92766)
Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)
Gene: RREB1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	35271311, 21258344, 23752268
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1687 Hs			1 488
+	Hs
		1038590 RREB1_HUMAN (1-1687): 0: 677: 93.82		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177344 RREB1_HUMAN (1-1687): 0: 677: 93.82		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		93753 ZN431_MOUSE (643-813): 2.11e-10: 67.4: 29.89		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1158943 ZFP1_HUMAN (1487-1562): 5.05e-09: 62.4: 40.74		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		93752 ZN431_MOUSE (643-813): 2.11e-10: 67.4: 29.89		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1193248 ZSCA2_HUMAN (896-1333): 9.96e-69: 246: 10.00		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Hs
		1246596 CTCFL_HUMAN (54-263): 9.58e-10: 65.5: 24.90		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04