Protein: SPT6
Transcription elongation factor SPT6 (Chromatin elongation factor SPT6)

Gene: SPT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P23615

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000791 - euchromatin
GO:0001073 - transcription antitermination factor activity, DNA binding
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

401895

RPB1
DNA-directed RNA polymerase II subunit RPB1

15

5

Small-scale

0.761

High

661197

IWS1
Transcription factor SPN1

15

3

Small-scale

0.761

High

661138

SPT6
Transcription elongation factor SPT6

2

9

Small-scale

0.755

High

632060

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

Small-scale

0.754

High

594204

RPB3
DNA-directed RNA polymerase II subunit RPB3

8

3

Small-scale

0.741

High

661142

SPT5
Transcription elongation factor SPT5

6

4

Small-scale

0.726

High

585860

CSK21
Casein kinase II subunit alpha

4

4

Small-scale

0.694

High

622874

CSK22
Casein kinase II subunit alpha'

3

8

Small-scale

0.678

High

661151

SPT16
FACT complex subunit SPT16

4

1

Small-scale

0.676

High

661184

H3
Histone H3

3

8

Small-scale

0.655

High

661193

POB3
FACT complex subunit POB3

3

2

High-throughput

0.633

High

381888

H4
Histone H4

3

6

Small-scale

0.625

High

543875

SSB1
Ribosome-associated molecular chaperone SSB1

3

7

High-throughput

0.624

High

661157

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.586

High

470467

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

1

High-throughput

0.584

High

661164

RPB11
DNA-directed RNA polymerase II subunit RPB11

2

1

Small-scale

0.584

High

392264

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

661174

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.567

High

661155

SPT4
Transcription elongation factor SPT4

2

0

High-throughput

0.559

High

523112

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

661198

CDC73
Cell division control protein 73

1

0

Small-scale

0.537

High

441332

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.536

High

574638

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.501

High

661150

HOG1
Mitogen-activated protein kinase HOG1

1

1

Small-scale

0.501

High

661162

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.493

High

661194

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.493

High

661167

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.486

High

661175

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.486

High

661181

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.486

High

419609

H2A2
Histone H2A.2

1

6

High-throughput

0.479

High

434844

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

514469

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

632127

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

632305

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

645024

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

661140

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

661141

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

661143

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

661144

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

661145

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.479

High

661146

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.479

High

661147

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

2

Small-scale

0.479

High

661148

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

661149

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

661159

CENPA
Histone H3-like centromeric protein CSE4

1

8

High-throughput

0.479

High

661160

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.479

High

661163

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.479

High

661171

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

661176

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

5

High-throughput

0.479

High

661185

SEN1
Helicase SEN1

1

1

High-throughput

0.479

High

661186

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

661187

NOP3
Serine/arginine

1

1

Small-scale

0.479

High

661190

ESP1
Separin

1

1

High-throughput

0.479

High

661191

CTK1
CTD kinase subunit alpha

1

1

Small-scale

0.479

High

661196

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

661201

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.479

High

661203

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

661204

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

148861

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.458

High

449398

SPT2
Protein SPT2

1

0

Small-scale

0.458

High

642005

DPOE
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.458

High

646303

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

661139

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

661152

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

High-throughput

0.458

High

661154

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

661158

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

661166

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

661172

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

661173

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

661177

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

661180

RTF1
RNA polymerase-associated protein RTF1

1

0

High-throughput

0.458

High

661182

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

661192

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

661199

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

661200

SGO1
Shugoshin

1

0

High-throughput

0.458

High

661165

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.457

High

380977

H2B1
Histone H2B.1

1

4

High-throughput

0.445

High

481491

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

525965

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

661161

SET3
SET domain-containing protein 3

1

4

High-throughput

0.445

High

661168

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

661189

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

9

High-throughput

0.445

High

435787

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

454890

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

460947

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.437

High

661153

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

661156

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

661188

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

661202

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

448135

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

661170

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.426

High

661183

SFB2
SED5-binding protein 2

1

0

High-throughput

0.279

Low

661195

POC1
Proteasome chaperone 1

1

0

High-throughput

0.269

Low

149599

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

358399

ADH2
Alcohol dehydrogenase 2

1

0

Small-scale

0.249

Low

409946

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

518212

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.249

Low

661178

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

661179

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

592025

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

661169

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025