HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: TRPS1 (Q9UHF7)
Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)
Gene: TRPS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	30071870, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 1281
+	Hs
		1038786 HDAC1_HUMAN (1-443): 0: 642: 90.07		TRPS1_HUMAN (1-1281): 0: 1888: 100.00
+	Hs
		1033690 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF1_HUMAN (781-1272): 5.18e-107: 349: 19.45
+	Hs
		1270517 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF2_HUMAN (800-1270): 2.98e-84: 287: 16.20
+	Hs
		1033633 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF1_HUMAN (781-1272): 5.18e-107: 349: 19.45
+	Hs
		1270518 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF3_HUMAN (850-1268): 4.38e-82: 280: 18.63
+	Hs
		1270436 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF4_HUMAN (771-1268): 1.19e-79: 276: 18.47
+	Hs
		1038804 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF2_HUMAN (800-1270): 2.98e-84: 287: 16.20
+	Hs
		1038805 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF3_HUMAN (850-1268): 4.38e-82: 280: 18.63
+	Hs
		798959 HDAC2_HUMAN (1-488): 0: 707: 100.00		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Mm
		570289 HDAC2_MOUSE (1-488): 0: 704: 99.39		GATA1_MOUSE (804-1033): 5.18e-40: 155: 20.21
+	Hs
		620541 HDAC2_HUMAN (1-488): 0: 707: 100.00		GATA3_HUMAN (870-1017): 3.94e-36: 144: 27.03
+	Hs
		798889 HDAC1_HUMAN (1-443): 0: 642: 90.07		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Mm
		140222 HDAC1_MOUSE (1-443): 0: 645: 90.29		GATA1_MOUSE (804-1033): 5.18e-40: 155: 20.21
+	Hs
		554447 HDAC1_HUMAN (1-443): 0: 642: 90.07		GATA1_HUMAN (804-1046): 1.3e-37: 148: 17.55
+	Hs
		620497 HDAC1_HUMAN (1-443): 0: 642: 90.07		GATA3_HUMAN (870-1017): 3.94e-36: 144: 27.03
+	Hs
		620344 HDAC1_HUMAN (1-443): 0: 642: 90.07		GATA2_HUMAN (821-1072): 2.62e-27: 119: 20.60
+	Hs
		177228 HDAC3_HUMAN (10-431): 0: 574: 58.26		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		177185 HDAC3_HUMAN (10-431): 0: 574: 58.26		GATA1_HUMAN (804-1046): 1.3e-37: 148: 17.55
+	Hs
		177196 HDAC3_HUMAN (10-431): 0: 574: 58.26		GATA3_HUMAN (870-1017): 3.94e-36: 144: 27.03
+	Hs
		177195 HDAC3_HUMAN (10-431): 0: 574: 58.26		GATA2_HUMAN (821-1072): 2.62e-27: 119: 20.60