HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: ZHX1 (Q9UKY1)
Zinc fingers and homeoboxes protein 1
Gene: ZHX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 873
+	Hs
		1038810 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZHX1_HUMAN (1-873): 0: 847: 100.00
+	Hs
		1270442 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZHX3_HUMAN (1-873): 0: 589: 32.70
+	Hs
		1038709 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZHX3_HUMAN (1-873): 0: 589: 32.70
+	Hs
		1270497 HDAC2_HUMAN (1-488): 0: 707: 100.00		DUX4_HUMAN (450-672): 2.35e-32: 132: 15.86
+	Hs
		1270550 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		741072 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZEB1_HUMAN (18-179): 9.39e-10: 64.8: 18.52
+	Hs
		231251 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZEB2_HUMAN (63-259): 2.75e-09: 63.2: 15.15
+	Hs
		1038497 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZFHX4_HUMAN (198-722): 3.99e-27: 121: 12.55
+	Hs
		1038860 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		1038413 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZFHX3_HUMAN (295-729): 4.4e-11: 69.4: 13.15
+	Hs
		741048 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZEB1_HUMAN (18-179): 9.39e-10: 64.8: 18.52
+	Hs
		231236 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZEB2_HUMAN (63-259): 2.75e-09: 63.2: 15.15
+	Hs
		177142 HDAC3_HUMAN (10-431): 0: 574: 58.26		ZEB2_HUMAN (63-259): 2.75e-09: 63.2: 15.15
+	Mm
		926111 HDA10_MOUSE (12-394): 1.09e-139: 418: 23.06		PAX6_MOUSE (628-784): 3.52e-12: 71.3: 18.29