Protein: MELK
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)

Gene: MELK
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q14680

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

719221

MPIP2
M-phase inducer phosphatase 2

2

1

Small-scale

0.806

High

821716

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.770

High

1129964

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.770

High

593369

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.691

High

854057

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

1110341

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

11

High-throughput

0.691

High

1130000

PCDG5
Protocadherin gamma-A5

3

3

High-throughput

0.662

High

1129945

MELK
Maternal embryonic leucine zipper kinase

1

16

Small-scale

0.647

High

1042618

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

653721

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.628

High

691007

1433T
14-3-3 protein theta

2

20

High-throughput

0.628

High

729839

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

966316

1433G
14-3-3 protein gamma

2

20

High-throughput

0.628

High

971530

1433E
14-3-3 protein epsilon

2

20

High-throughput

0.628

High

1049294

1433F
14-3-3 protein eta

2

20

High-throughput

0.628

High

1128892

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.628

High

74486

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.618

High

176824

DCLK1
Serine/threonine-protein kinase DCLK1

1

14

High-throughput

0.618

High

245230

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

16

High-throughput

0.618

High

291794

STK16
Serine/threonine-protein kinase 16

1

16

High-throughput

0.618

High

581052

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

955175

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

988370

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1025542

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.618

High

1105922

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.618

High

1107719

SQSTM
Sequestosome-1

1

2

High-throughput

0.618

High

1129960

KSR1
Kinase suppressor of Ras 1

1

14

High-throughput

0.618

High

1129973

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.618

High

1129982

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.618

High

1129983

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1129985

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.618

High

1129988

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.618

High

1129977

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.609

High

391257

FRIL
Ferritin light chain

2

2

High-throughput

0.601

High

1129993

PNMA2
Paraneoplastic antigen Ma2

2

8

High-throughput

0.601

High

1129978

RTKN
Rhotekin

1

0

High-throughput

0.586

High

231574

PRKY
Putative serine/threonine-protein kinase PRKY

1

17

High-throughput

0.575

High

990227

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.574

High

1129980

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

Small-scale

0.561

High

1129979

LST8
Target of rapamycin complex subunit LST8

2

2

High-throughput

0.558

High

830737

CCNF
Cyclin-F

1

2

High-throughput

0.553

High

1129947

ZN638
Zinc finger protein 638

1

4

High-throughput

0.553

High

1129955

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.553

High

1129956

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

1129966

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.553

High

1129995

PPM1H
Protein phosphatase 1H

1

17

High-throughput

0.553

High

1129996

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.553

High

1060873

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.536

High

1129958

RUFY3
Protein RUFY3

1

5

High-throughput

0.536

High

1129974

CDC5L
Cell division cycle 5-like protein

1

10

High-throughput

0.536

High

1129981

CAD23
Cadherin-23

1

2

High-throughput

0.536

High

1129999

PCDB6
Protocadherin beta-6

1

3

High-throughput

0.536

High

1130001

PCDG4
Protocadherin gamma-A4

1

3

High-throughput

0.536

High

1130002

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

1129994

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.517

High

220163

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.513

High

529802

TAU
Microtubule-associated protein tau

1

8

Small-scale

0.501

High

634441

LMNB1
Lamin-B1

1

3

Small-scale

0.501

High

289352

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.489

High

848485

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.489

High

997341

TBB4B
Tubulin beta-4B chain

1

5

High-throughput

0.489

High

1129948

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.489

High

388071

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

208666

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

1095631

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

13

High-throughput

0.479

High

1113114

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1129954

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1129959

TAXB1
Tax1-binding protein 1

1

13

High-throughput

0.479

High

1129972

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.479

High

1129976

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1129989

CING
Cingulin

1

6

High-throughput

0.479

High

1129990

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1129992

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

9

High-throughput

0.479

High

1129998

KCTD3
BTB/POZ domain-containing protein KCTD3

1

6

High-throughput

0.479

High

1129950

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.470

High

1129967

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

Small-scale

0.460

High

269551

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

293692

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

1129975

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1010917

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

1129946

SL9A5
Sodium/hydrogen exchanger 5

1

4

High-throughput

0.445

High

252066

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.437

High

281323

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.437

High

372033

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.437

High

940963

HDAC4
Histone deacetylase 4

1

8

High-throughput

0.437

High

1045286

TF65
Transcription factor p65

1

3

High-throughput

0.437

High

1129952

RC3H1
Roquin-1

1

4

High-throughput

0.437

High

1129953

SPD2A
SH3 and PX domain-containing protein 2A

1

7

High-throughput

0.437

High

1129957

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.437

High

1129962

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1129965

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.437

High

1129991

XPO7
Exportin-7

1

5

High-throughput

0.437

High

1129997

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

1118473

TBB2A
Tubulin beta-2A chain

1

5

High-throughput

0.407

High

1129984

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1129963

RHPN1
Rhophilin-1

2

0

High-throughput

0.328

High

1129968

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

567862

PRG2
Bone marrow proteoglycan

2

0

High-throughput

0.318

High

1129949

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

Small-scale

0.292

High

191331

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.279

Low

342563

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

935732

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

1101334

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1103092

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1129951

PSMG4
Proteasome assembly chaperone 4

1

0

High-throughput

0.279

Low

1129961

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

1129969

PSMG2
Proteasome assembly chaperone 2

1

0

High-throughput

0.279

Low

1129970

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1129986

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.279

Low

1129971

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

1129987

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025