HitPredict

Interactor 1: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29089450
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 1116
+	Hs
		200789 ARHG9_HUMAN (162-599): 2.49e-92: 305: 12.45		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		1273277 ARHG2_HUMAN (1-986): 0: 736: 100.00		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		125623 ARHG2_HUMAN (1-986): 0: 736: 100.00		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		1022406 TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		1170401 ARHGI_HUMAN (1-982): 5.42e-125: 414: 30.77		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Ce
		136804 VAV_CAEEL (35-839): 2.53e-91: 315: 12.97		UNC89_CAEEL (727-1109): 1.99e-56: 217: 12.25
+	Hs
		1136429 ARHG8_HUMAN (128-637): 9.09e-48: 182: 17.75		MAGI3_HUMAN (1-1116): 3.96e-94: 331: 9.76
+	Hs
		1331486 ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Mm
		1194490 ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00		CNKR2_MOUSE (120-329): 2.5e-47: 186: 26.94
+	Hs
		855823 VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		1022438 TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		1127536 FGD3_HUMAN (94-769): 6.53e-90: 304: 15.08		RHG22_HUMAN (139-751): 3.05e-43: 170: 15.09
+	Hs
		167092 ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Mm
		57863 KALRN_MOUSE (224-886): 3.77e-76: 276: 12.32		CNKR2_MOUSE (120-329): 2.5e-47: 186: 26.94
+	Hs
		1049723 ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		1272198 ARHG1_HUMAN (31-698): 5.2e-86: 298: 21.49		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		855816 VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		1078893 ITSN1_HUMAN (222-600): 5.07e-70: 257: 22.28		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		1137771 OBSCN_HUMAN (181-949): 2.83e-85: 304: 13.20		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Mm
		1164175 ARHG8_MOUSE (128-575): 5.66e-48: 183: 18.30		MAGI1_MOUSE (1-1097): 9.62e-48: 188: 10.27