Protein: HS2ST
Heparan sulfate 2-O-sulfotransferase 1 (EC 2.8.2.-) (2-O-sulfotransferase) (2-OST) (2OST) (HS 2-O-sulfotransferase) (Heparan sulfate 2-sulfotransferase)

Gene: HS2ST, HS2ST1
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q7LGA3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004394 - heparan sulfate 2-sulfotransferase activity
GO:0010467 - gene expression
GO:0015012 - heparan sulfate proteoglycan biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

722504

CTR1
High affinity cationic amino acid transporter 1

4

4

High-throughput

0.687

High

1273237

DYM
Dymeclin

4

0

High-throughput

0.661

High

1273284

DIAP3
Protein diaphanous homolog 3

4

0

High-throughput

0.661

High

828387

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

1058485

CKAP4
Cytoskeleton-associated protein 4

3

0

High-throughput

0.638

High

931257

AT12A
Potassium-transporting ATPase alpha chain 2

3

3

High-throughput

0.609

High

1273248

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.602

High

1224741

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.576

High

1273274

PIGS
GPI-anchor transamidase component PIGS

2

0

High-throughput

0.576

High

1273293

P2RX2
P2X purinoceptor 2

2

1

High-throughput

0.574

High

409433

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

1

High-throughput

0.571

High

1273278

P2RX4
P2X purinoceptor 4

2

1

High-throughput

0.571

High

242113

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

458439

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.541

High

173970

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.536

High

182623

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

565648

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.536

High

607382

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

669016

FPR2
N-formyl peptide receptor 2

1

4

High-throughput

0.536

High

698815

CALX
Calnexin

1

3

High-throughput

0.536

High

1273263

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1273266

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.536

High

1273300

XCT
Cystine/glutamate transporter

1

4

High-throughput

0.536

High

1273304

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.536

High

218377

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.533

High

923423

SC5A3
Sodium/myo-inositol cotransporter

2

0

High-throughput

0.528

High

181348

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

212581

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.513

High

328819

CSPG5
Chondroitin sulfate proteoglycan 5

1

0

High-throughput

0.513

High

341434

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

422428

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

528764

MGST1
Microsomal glutathione S-transferase 1

1

0

High-throughput

0.513

High

618194

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

0

High-throughput

0.513

High

624199

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

727866

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.513

High

888910

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

898102

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.513

High

1065959

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.513

High

1097813

STX5
Syntaxin-5

1

0

High-throughput

0.513

High

1143629

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

1179658

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.513

High

1216299

MTCL3
Microtubule cross-linking factor 3

1

0

High-throughput

0.513

High

1273238

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.513

High

1273242

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.513

High

1273250

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

1273254

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1273260

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.513

High

1273265

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

1273268

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

1273275

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1273277

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

1273279

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.513

High

1273282

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

1273283

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1273286

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

0

High-throughput

0.513

High

1273289

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.513

High

167618

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

833831

P2RY2
P2Y purinoceptor 2

1

2

High-throughput

0.489

High

1143728

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.489

High

1143827

PON3
Serum paraoxonase/lactonase 3

1

2

High-throughput

0.489

High

1273288

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.489

High

1113518

CUL3
Cullin-3

1

1

High-throughput

0.479

High

560432

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

867240

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

958568

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

0

High-throughput

0.458

High

1273281

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.458

High

1273298

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

High-throughput

0.458

High

870251

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

870369

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

1131557

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1139472

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

1273245

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.445

High

1273249

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

1273251

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

1273295

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.445

High

472321

CFAH
Complement factor H

1

1

Small-scale

0.437

High

178306

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.426

High

256065

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

351229

MOT3
Monocarboxylate transporter 3

1

0

High-throughput

0.426

High

776979

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.426

High

907717

CLCN3
H(+)/Cl(-) exchange transporter 3

1

0

High-throughput

0.426

High

1034013

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1175870

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1236198

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1242147

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

1273239

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

1273240

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.426

High

1273246

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

1273252

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

170838

CLGN
Calmegin

1

3

High-throughput

0.407

High

303243

S22A5
Organic cation/carnitine transporter 2

1

4

High-throughput

0.407

High

652206

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

669339

ACKR3
Atypical chemokine receptor 3

1

4

High-throughput

0.407

High

912687

CTR2
Cationic amino acid transporter 2

1

4

High-throughput

0.407

High

1179002

S35G1
Solute carrier family 35 member G1

1

3

High-throughput

0.407

High

1211921

S35F1
Solute carrier family 35 member F1

1

3

High-throughput

0.407

High

1246080

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.407

High

1273243

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

1273247

SVOP
Synaptic vesicle 2-related protein

1

4

High-throughput

0.407

High

1273253

S7A14
Solute carrier family 7 member 14

1

4

High-throughput

0.407

High

1273257

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.407

High

1273259

SL9A6
Sodium/hydrogen exchanger 6

1

1

High-throughput

0.407

High

1273280

S22A4
Solute carrier family 22 member 4

1

4

High-throughput

0.407

High

1273303

S22AE
Solute carrier family 22 member 14

1

4

High-throughput

0.407

High

1273276

NMNA3
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

3

0

High-throughput

0.347

High

1273287

TBC23
TBC1 domain family member 23

3

0

High-throughput

0.347

High

1273269

TSN17
Tetraspanin-17

2

0

High-throughput

0.318

High

1273267

SAAL1
Protein SAAL1

2

0

High-throughput

0.313

High

62215

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.279

Low

138928

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

0

High-throughput

0.279

Low

193592

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.279

Low

220176

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

260899

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

460262

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.279

Low

1116722

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.279

Low

1157619

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.279

Low

1202197

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.279

Low

1235403

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1251662

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1273244

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1273255

SCFD2
Sec1 family domain-containing protein 2

1

0

High-throughput

0.279

Low

1273258

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1273264

YIPF5
Protein YIPF5

1

0

High-throughput

0.279

Low

1273271

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.279

Low

1273272

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

1273273

LMF1
Lipase maturation factor 1

1

0

High-throughput

0.279

Low

1273285

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.279

Low

1273290

USE1
Vesicle transport protein USE1

1

0

High-throughput

0.279

Low

1273292

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.279

Low

1273301

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.279

Low

1273262

KLK6
Kallikrein-6

1

0

High-throughput

0.268

Low

185808

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

133763

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.249

Low

521777

H14
Histone H1.4

1

0

High-throughput

0.249

Low

589016

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695803

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768514

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

830971

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

937800

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1048017

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.249

Low

1107861

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

1220998

FBW10
F-box/WD repeat-containing protein 10

1

0

High-throughput

0.249

Low

1248970

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1254392

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1273261

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1273270

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1273291

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1273294

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.249

Low

1273296

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1273297

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

0

High-throughput

0.249

Low

1273299

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1273302

ABEC2
C->U-editing enzyme APOBEC-2

1

0

High-throughput

0.249

Low

511035

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low

848789

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.232

Low

1273071

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.232

Low

1273241

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

0

High-throughput

0.232

Low

1273256

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025