HitPredict

Interactor 1: MIB2 (Q96AX9)
E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)
Gene: MIB2

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.657

Property	Details
Experiments	25565632, 31366726
Identification Methods	affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 955 Hs			1 956
+	Hs
		1206067 MIB1_HUMAN (11-954): 0: 611: 36.35		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		556721 ANK1_HUMAN (626-955): 8.19e-47: 185: 14.89		CYLD_HUMAN (1-956): 0: 1872: 100.00