HitPredict

Interactor 1: OTUL (Q96BN8)
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)
Gene: OTULIN

Interactor 2: SHRPN (Q9H0F6)
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)
Gene: SHARPIN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.702

The method score is based on:

Property Details
Experiments 27591049, 23746843, 26670046, 28919039, 24726323
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway
GO:0050728 - negative regulation of inflammatory response
GO:0071797 - LUBAC complex
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 352
Hs

1 387
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024