HitPredict

Interactor 1: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29661858
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0032481 - positive regulation of type I interferon production GO:0140374 - antiviral innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 678 Hs			1 522
+	Hs
		1020856 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		129586 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1024728 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		761822 RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88		TRAF2_MOUSE (40-500): 3.02e-101: 315: 26.05
+	Hs
		1052729 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		321891 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1052762 IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Mm
		1111925 SMCA4_MOUSE (3-592): 1.63e-74: 264: 12.94		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Mm
		1163172 RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88		TRI11_MOUSE (59-404): 7.41e-48: 174: 12.75
+	Mm
		1142634 RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88		TRI25_MOUSE (61-368): 9.52e-45: 168: 15.22
+	Hs
		321897 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		321932 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		TRIM6_HUMAN (56-403): 5.03e-39: 150: 12.97
+	Hs
		1052806 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		1290201 IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83
+	Hs
		1318527 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1052656 CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		536834 CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		321926 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83
+	Hs
		536917 FANCM_HUMAN (4-542): 6.34e-65: 235: 17.68		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1101003 DDX24_HUMAN (3-557): 6.6e-57: 209: 14.35		RN151_HUMAN (54-204): 2.32e-33: 128: 28.03