Interactor 1: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 20479254, 34163012
Identification Methods enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SIR2~SIR2
Common GO terms GO:0000012 - single strand break repair
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 - DNA synthesis involved in DNA repair
and 150 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 747
Hs

1 747
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Hs
+ Hs
+ Sc
+ Sc
+ Ec
+ Hp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024