Interactor 1: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Interactor 2: TLN2 (Q9Y4G6)
Talin-2
Gene: TLN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 38334954, 31839598, 34349018, 35235311
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_N~FERM_f0, FERM_M~FERM_M, FERM_M~FERM_N, FERM_M~IRS, FERM_M~Talin_IBS2B, I_LWEQ~I_LWEQ, I_LWEQ~Talin_IBS2B, I_LWEQ~TLN1-like_RS, I_LWEQ~VBS, FERM_N~IRS, IRS~IRS, IRS~TLN1-like_RS, Talin_IBS2B~Talin_middle, Talin_IBS2B~Talin_R4, TLN1-like_RS~Talin_IBS2B, Talin_middle~Talin_middle, Talin_R4~Talin_middle, TLN1-like_RS~Talin_middle, TLN1-like_RS~Talin_R4, Talin_R4~VBS and 1 others

more...

Common GO terms GO:0001726 - ruffle
GO:0005178 - integrin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
and 4 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 2541
Hs

1 2542
+ Dm
+ Dm
+ Hs
+ Dm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
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+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025