Protein: FERM2
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)

Gene: FERM2, FERMT2
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q96AC1

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0005178 - integrin binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1349262

WDR20
WD repeat-containing protein 20

3

1

High-throughput

0.855

High

1104455

ILK
Scaffold protein ILK

2

6

Small-scale

0.812

High

1289389

URP2
Fermitin family homolog 3

2

5

High-throughput

0.811

High

1382769

FERM1
Fermitin family homolog 1

2

5

High-throughput

0.811

High

375816

RASK
GTPase KRas

2

6

High-throughput

0.754

High

582913

EZRI
Ezrin

2

3

High-throughput

0.754

High

978218

RHOB
Rho-related GTP-binding protein RhoB

2

12

High-throughput

0.754

High

1357064

FBLI1
Filamin-binding LIM protein 1

1

5

Small-scale

0.740

High

975169

ARF6
ADP-ribosylation factor 6

2

0

High-throughput

0.716

High

976473

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.716

High

870152

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

5

Small-scale

0.647

High

764953

CTNB1
Catenin beta-1

2

1

Small-scale

0.646

High

1382779

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

2

Small-scale

0.634

High

1382781

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

2

3

High-throughput

0.621

High

126737

RHOD
Rho-related GTP-binding protein RhoD

1

14

High-throughput

0.618

High

247404

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

3

High-throughput

0.618

High

341121

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.618

High

363685

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.618

High

374119

RASN
GTPase NRas

1

6

High-throughput

0.618

High

374832

RASH
GTPase HRas

1

4

High-throughput

0.618

High

412402

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.618

High

440169

LCK
Tyrosine-protein kinase Lck

1

4

High-throughput

0.618

High

463697

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.618

High

465607

IGF1R
Insulin-like growth factor 1 receptor

1

11

High-throughput

0.618

High

466401

RHOC
Rho-related GTP-binding protein RhoC

1

10

High-throughput

0.618

High

541628

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.618

High

557420

SRC
Proto-oncogene tyrosine-protein kinase Src

1

4

Small-scale

0.618

High

581221

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.618

High

601402

RHOQ
Rho-related GTP-binding protein RhoQ

1

12

High-throughput

0.618

High

631397

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.618

High

648621

FGFR4
Fibroblast growth factor receptor 4

1

9

High-throughput

0.618

High

710416

EPHA2
Ephrin type-A receptor 2

1

5

High-throughput

0.618

High

710875

EPHB2
Ephrin type-B receptor 2

1

4

High-throughput

0.618

High

878531

PAXI
Paxillin

1

6

High-throughput

0.618

High

900975

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.618

High

901990

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.618

High

932112

EPHA4
Ephrin type-A receptor 4

1

6

High-throughput

0.618

High

953608

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.618

High

955456

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.618

High

956440

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.618

High

962360

RHOA
Transforming protein RhoA

1

11

High-throughput

0.618

High

962804

RND3
Rho-related GTP-binding protein RhoE

1

14

High-throughput

0.618

High

988595

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.618

High

1015662

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.618

High

1115884

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.618

High

1116438

FHL1
Four and a half LIM domains protein 1

1

6

Small-scale

0.618

High

1145051

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1146446

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.618

High

1147403

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.618

High

1151817

RHOH
Rho-related GTP-binding protein RhoH

1

12

High-throughput

0.618

High

1157025

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.618

High

1187523

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.618

High

1270940

RHOU
Rho-related GTP-binding protein RhoU

1

14

High-throughput

0.618

High

1363810

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.618

High

1366860

RND1
Rho-related GTP-binding protein Rho6

1

14

High-throughput

0.618

High

1382764

RHOV
Rho-related GTP-binding protein RhoV

1

12

High-throughput

0.618

High

1382775

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.618

High

1382777

RHOF
Rho-related GTP-binding protein RhoF

1

13

High-throughput

0.618

High

1382780

E41LA
Band 4.1-like protein 4A

1

1

High-throughput

0.618

High

1382792

ALK
ALK tyrosine kinase receptor

1

10

High-throughput

0.618

High

366255

FA9
Coagulation factor IX

2

0

High-throughput

0.602

High

1215245

RIPP2
Protein ripply2

2

0

High-throughput

0.602

High

157710

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.586

High

605776

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.586

High

242523

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

540611

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.584

High

142387

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.575

High

941825

ARL4C
ADP-ribosylation factor-like protein 4C

1

2

High-throughput

0.575

High

1209486

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

1382762

AURKB
Aurora kinase B

1

1

High-throughput

0.575

High

1382793

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.575

High

1382786

ARL15
ADP-ribosylation factor-like protein 15

1

2

High-throughput

0.553

High

587175

ITF2
Transcription factor 4

1

0

Small-scale

0.541

High

909651

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.515

High

186165

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

0

High-throughput

0.513

High

872613

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1144112

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1382766

PRRC1
Protein PRRC1

1

0

High-throughput

0.513

High

1382787

EHD3
EH domain-containing protein 3

1

0

High-throughput

0.513

High

422812

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

431867

ITB1
Integrin beta-1

1

17

Small-scale

0.501

High

1382784

PARVA
Alpha-parvin

1

3

Small-scale

0.501

High

1257192

BBS12
Chaperonin-containing T-complex member BBS12

1

0

High-throughput

0.493

High

1382770

TRI15
E3 ubiquitin-protein ligase TRIM15

1

2

Small-scale

0.481

High

173185

XPO1
Exportin-1

1

1

High-throughput

0.479

High

189763

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

346167

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

372780

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

414364

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

487617

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

562292

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

589353

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

604146

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

612106

ITB5
Integrin beta-5

1

17

Small-scale

0.479

High

643013

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

764405

CTNA1
Catenin alpha-1

1

3

Small-scale

0.479

High

768837

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

791611

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

845749

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

934965

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

1041222

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1087233

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1254961

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1258363

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

1276604

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1289518

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1322934

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1334735

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1350399

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

1382760

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

1382774

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1382778

CPAP
Centrosomal P4.1-associated protein

1

1

High-throughput

0.479

High

1382790

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.479

High

1382791

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1382794

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

154503

CLD4
Claudin-4

1

0

Small-scale

0.458

High

218599

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

227122

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

299325

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

327402

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

715713

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

896603

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

994705

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.458

High

1004157

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1108009

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1114989

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1159796

OCLN
Occludin

1

0

High-throughput

0.458

High

1233404

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1322770

CNTRB
Centrobin

1

0

High-throughput

0.458

High

1382765

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1382768

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

472956

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.457

High

1040352

DYST
Dystonin

1

3

High-throughput

0.457

High

1234408

CAPR2
Caprin-2

1

1

High-throughput

0.457

High

1382763

FEM1C
Protein fem-1 homolog C

1

1

High-throughput

0.457

High

1382782

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

1382789

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

1

High-throughput

0.457

High

457605

TBB5
Tubulin beta chain

1

1

High-throughput

0.445

High

1118551

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.445

High

139378

NCHL1
Neural cell adhesion molecule L1-like protein

1

0

High-throughput

0.438

High

220663

SYT7
Synaptotagmin-7

1

0

High-throughput

0.438

High

658920

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

0

High-throughput

0.438

High

106420

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1256547

CE128
Centrosomal protein of 128 kDa

1

2

High-throughput

0.437

High

143751

WN10B
Protein Wnt-10b

1

0

High-throughput

0.426

High

330265

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

598759

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

638489

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.426

High

967165

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.426

High

1340494

DNJB8
DnaJ homolog subfamily B member 8

1

0

High-throughput

0.426

High

1382773

NXF5
Nuclear RNA export factor 5

1

0

High-throughput

0.426

High

1382783

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1382785

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.426

High

653487

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

1382771

LRC27
Leucine-rich repeat-containing protein 27

1

2

High-throughput

0.407

High

1382795

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.328

High

692476

G0S2
G0/G1 switch protein 2

1

0

High-throughput

0.279

Low

1382776

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1382788

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

1382761

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.265

Low

698988

CALX
Calnexin

1

0

High-throughput

0.249

Low

1293107

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1381930

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1382767

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.249

Low

1382772

ADSSP
Adipose-secreted signaling protein

1

0

High-throughput

0.238

Low

1104042

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025