HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: CE192 (Q8TEP8)
Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)
Gene: CEP192

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.649

The method score is based on:

Property Details
Experiments 24997597, 26188084
Identification Methods x-ray crystallography, anti tag coimmunoprecipitation, pull down, molecular sieving, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005813 - centrosome
GO:0005814 - centriole
GO:0005829 - cytosol
GO:0007099 - centriole replication
GO:0120098 - procentriole
and 1 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 970
Hs

1 2537
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024