HitPredict

Interactor 1: MED8 (Q96G25)
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Gene: MED8

Interactor 2: MED30 (Q96HR3)
Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
Gene: MED30

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

The method score is based on:

Property	Details
Experiments	12584197, 24882805, 24981860, 35271311
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex and 6 others more... GO:0016567 - protein ubiquitination GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061630 - ubiquitin protein ligase activity GO:0070847 - core mediator complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	268
Hs

1	178

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024