Protein: PAR2
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]

Gene: PAR2, F2RL1
Organism: Homo sapiens
Interactions: 179
UniProt ID: P55085

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0002020 - protease binding
GO:0002286 - T cell activation involved in immune response
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0002720 - positive regulation of cytokine production involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867703

RGR
RPE-retinal G protein-coupled receptor

1

17

High-throughput

0.698

High

182502

GP182
G-protein coupled receptor 182

1

17

High-throughput

0.691

High

936030

CXCR4
C-X-C chemokine receptor type 4

1

19

High-throughput

0.691

High

936046

SLMAP
Sarcolemmal membrane-associated protein

3

2

High-throughput

0.667

High

936035

SCN1B
Sodium channel regulatory subunit beta-1

1

0

High-throughput

0.663

High

936141

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.625

High

936052

TMED2
Transmembrane emp24 domain-containing protein 2

2

7

Small-scale

0.608

High

936099

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.594

High

598047

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

20

High-throughput

0.582

High

936115

PTSS2
Phosphatidylserine synthase 2

2

10

High-throughput

0.578

High

936074

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

2

4

High-throughput

0.574

High

936103

INT12
Integrator complex subunit 12

2

6

High-throughput

0.574

High

385597

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

4

High-throughput

0.560

High

211768

ZW10
Centromere/kinetochore protein zw10 homolog

2

5

High-throughput

0.558

High

936028

GEMI4
Gem-associated protein 4

2

4

High-throughput

0.558

High

936068

RINT1
RAD50-interacting protein 1

2

7

High-throughput

0.558

High

190552

COPT2
Protein SLC31A2

1

1

High-throughput

0.541

High

354105

CLPT1
Putative lipid scramblase CLPTM1

1

8

High-throughput

0.541

High

412946

CPNS1
Calpain small subunit 1

1

3

High-throughput

0.541

High

477412

CD63
CD63 antigen

1

19

High-throughput

0.541

High

568049

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

3

High-throughput

0.541

High

610281

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.541

High

627291

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

20

High-throughput

0.541

High

719891

HMOX2
Heme oxygenase 2

1

5

High-throughput

0.541

High

774240

BASI
Basigin

1

5

High-throughput

0.541

High

845201

SATT
Neutral amino acid transporter A

1

3

High-throughput

0.541

High

936029

CD81
CD81 antigen

1

16

High-throughput

0.541

High

936032

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.541

High

936037

ADCY2
Adenylate cyclase type 2

1

2

High-throughput

0.541

High

936038

ABCC8
ATP-binding cassette sub-family C member 8

1

8

High-throughput

0.541

High

936042

TMED1
Transmembrane emp24 domain-containing protein 1

1

7

High-throughput

0.541

High

936077

PRRT2
Proline-rich transmembrane protein 2

1

10

High-throughput

0.541

High

936102

LFG3
Protein lifeguard 3

1

5

High-throughput

0.541

High

936110

S39AD
Zinc transporter ZIP13

1

20

High-throughput

0.541

High

936121

S12A5
Solute carrier family 12 member 5

1

19

High-throughput

0.541

High

936122

PIGU
GPI-anchor transamidase component PIGU

1

4

High-throughput

0.541

High

936128

RTN4
Reticulon-4

1

9

High-throughput

0.541

High

936143

YIPF1
Protein YIPF1

1

12

High-throughput

0.541

High

219290

B4GA1
Beta-1,4-glucuronyltransferase 1

1

1

High-throughput

0.536

High

251078

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.536

High

252672

TSN3
Tetraspanin-3

1

20

High-throughput

0.536

High

419976

B3A2
Anion exchange protein 2

1

6

High-throughput

0.536

High

443734

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

10

High-throughput

0.536

High

463034

YES
Tyrosine-protein kinase Yes

1

14

High-throughput

0.536

High

463422

LYN
Tyrosine-protein kinase Lyn

1

14

High-throughput

0.536

High

557190

SRC
Proto-oncogene tyrosine-protein kinase Src

1

14

High-throughput

0.536

High

565590

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

680292

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

10

High-throughput

0.536

High

690211

STOM
Stomatin

1

5

High-throughput

0.536

High

931221

AT12A
Potassium-transporting ATPase alpha chain 2

1

20

High-throughput

0.536

High

931326

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

3

High-throughput

0.536

High

936033

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.536

High

936040

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.536

High

936041

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.536

High

936057

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

10

High-throughput

0.536

High

936063

TM63B
Mechanosensitive cation channel TMEM63B

1

3

High-throughput

0.536

High

936065

RIF1
Telomere-associated protein RIF1

1

6

High-throughput

0.536

High

936072

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

15

High-throughput

0.536

High

936075

DYM
Dymeclin

1

8

High-throughput

0.536

High

936078

TMED4
Transmembrane emp24 domain-containing protein 4

1

5

High-throughput

0.536

High

936079

ZDH17
Palmitoyltransferase ZDHHC17

1

11

High-throughput

0.536

High

936090

GOGA5
Golgin subfamily A member 5

1

8

High-throughput

0.536

High

936092

CIP2A
Protein CIP2A

1

7

High-throughput

0.536

High

936097

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

13

High-throughput

0.536

High

936105

COQ8B
Atypical kinase COQ8B, mitochondrial

1

10

High-throughput

0.536

High

936108

TSN17
Tetraspanin-17

1

16

High-throughput

0.536

High

936112

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.536

High

936119

YIPF3
Protein YIPF3

1

8

High-throughput

0.536

High

936120

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.536

High

105648

APRIO
Alternative prion protein

1

3

High-throughput

0.523

High

564906

ICAM2
Intercellular adhesion molecule 2

1

0

High-throughput

0.518

High

764290

CTNA1
Catenin alpha-1

1

0

High-throughput

0.518

High

936031

S35A1
CMP-sialic acid transporter

1

0

High-throughput

0.518

High

936084

LAT4
Large neutral amino acids transporter small subunit 4

1

0

High-throughput

0.518

High

936124

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.518

High

260849

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

936055

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

936096

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

404745

PRIO
Major prion protein

1

3

High-throughput

0.506

High

516191

HS71B
Heat shock 70 kDa protein 1B

1

1

High-throughput

0.506

High

226422

SNG2
Synaptogyrin-2

1

3

High-throughput

0.494

High

301380

WFS1
Wolframin

1

2

High-throughput

0.494

High

337290

CXB6
Gap junction beta-6 protein

1

11

High-throughput

0.494

High

664963

ERD21
ER lumen protein-retaining receptor 1

1

8

High-throughput

0.494

High

698527

CALX
Calnexin

1

3

High-throughput

0.494

High

936036

KLC1
Kinesin light chain 1

1

1

High-throughput

0.494

High

936044

MFS10
Major facilitator superfamily domain-containing protein 10

1

8

High-throughput

0.494

High

936047

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

1

High-throughput

0.494

High

936053

CNN3
Calponin-3

1

2

High-throughput

0.494

High

936056

RTN1
Reticulon-1

1

9

High-throughput

0.494

High

936061

PPM1J
Protein phosphatase 1J

1

1

High-throughput

0.494

High

936064

CXG2
Gap junction gamma-2 protein

1

11

High-throughput

0.494

High

936067

S18B1
MFS-type transporter SLC18B1

1

3

High-throughput

0.494

High

936088

MORN4
MORN repeat-containing protein 4

1

5

High-throughput

0.494

High

936093

NAT14
Probable N-acetyltransferase 14

1

3

High-throughput

0.494

High

936094

PHLA1
Pleckstrin homology-like domain family A member 1

1

1

High-throughput

0.494

High

936106

YIPF6
Protein YIPF6

1

7

High-throughput

0.494

High

936129

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

1

High-throughput

0.494

High

936133

T161A
Transmembrane protein 161A

1

6

High-throughput

0.494

High

936140

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

4

High-throughput

0.494

High

651240

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.493

High

164555

TNPO2
Transportin-2

1

11

High-throughput

0.489

High

173686

BTAF1
TATA-binding protein-associated factor 172

1

8

High-throughput

0.489

High

189134

IPO8
Importin-8

1

19

High-throughput

0.489

High

208037

TTI1
TELO2-interacting protein 1 homolog

1

5

High-throughput

0.489

High

299633

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

1

High-throughput

0.489

High

318127

IPO13
Importin-13

1

20

High-throughput

0.489

High

397793

ATP8
ATP synthase F(0) complex subunit 8

1

1

High-throughput

0.489

High

665561

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

5

High-throughput

0.489

High

784560

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

3

High-throughput

0.489

High

936027

SYJ2B
Synaptojanin-2-binding protein

1

20

High-throughput

0.489

High

936034

TAP1
Antigen peptide transporter 1

1

11

High-throughput

0.489

High

936050

OXA1L
Mitochondrial inner membrane protein OXA1L

1

3

High-throughput

0.489

High

936051

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.489

High

936060

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

20

High-throughput

0.489

High

936066

TBC9B
TBC1 domain family member 9B

1

6

High-throughput

0.489

High

936069

ARMC6
Armadillo repeat-containing protein 6

1

4

High-throughput

0.489

High

936070

BRAT1
Integrator complex assembly factor BRAT1

1

6

High-throughput

0.489

High

936073

THADA
tRNA

1

7

High-throughput

0.489

High

936076

MON2
Protein MON2 homolog

1

19

High-throughput

0.489

High

936081

MIRO2
Mitochondrial Rho GTPase 2

1

18

High-throughput

0.489

High

936082

K2013
Uncharacterized protein KIAA2013

1

7

High-throughput

0.489

High

936083

INT1
Integrator complex subunit 1

1

9

High-throughput

0.489

High

936089

ATLA2
Atlastin-2

1

15

High-throughput

0.489

High

936091

TBC15
TBC1 domain family member 15

1

9

High-throughput

0.489

High

936098

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.489

High

936100

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

936104

F241B
Protein FAM241B

1

4

High-throughput

0.489

High

936107

HOOK2
Protein Hook homolog 2

1

8

High-throughput

0.489

High

936109

RUSF1
RUS family member 1

1

6

High-throughput

0.489

High

936111

CP2S1
Cytochrome P450 2S1

1

3

High-throughput

0.489

High

936116

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.489

High

936117

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.489

High

936118

XPO4
Exportin-4

1

20

High-throughput

0.489

High

936123

HEAT1
HEAT repeat-containing protein 1

1

4

High-throughput

0.489

High

936125

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.489

High

936126

COG4
Conserved oligomeric Golgi complex subunit 4

1

5

High-throughput

0.489

High

936127

XPO5
Exportin-5

1

20

High-throughput

0.489

High

936130

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

8

High-throughput

0.489

High

936131

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.489

High

936132

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.489

High

936135

CS025
UPF0449 protein C19orf25

1

3

High-throughput

0.489

High

936136

IPO11
Importin-11

1

20

High-throughput

0.489

High

936139

TMCO1
Calcium load-activated calcium channel

1

5

High-throughput

0.489

High

936142

TELO2
Telomere length regulation protein TEL2 homolog

1

4

High-throughput

0.489

High

936144

TNPO3
Transportin-3

1

20

High-throughput

0.489

High

936145

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

5

High-throughput

0.489

High

126300

TLR4
Toll-like receptor 4

1

1

Small-scale

0.479

High

287541

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

Small-scale

0.479

High

814772

CUX1
Homeobox protein cut-like 1

1

10

High-throughput

0.479

High

888837

TMEDA
Transmembrane emp24 domain-containing protein 10

1

5

Small-scale

0.479

High

567773

TF
Tissue factor

1

0

Small-scale

0.458

High

936045

Q14868
Effector cell protease receptor 1

1

0

Small-scale

0.458

High

839445

PI4KA
Phosphatidylinositol 4-kinase alpha

1

19

High-throughput

0.445

High

936043

CASP
Protein CASP

1

8

High-throughput

0.445

High

188657

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

Small-scale

0.437

High

293432

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

936054

SAFB1
Scaffold attachment factor B1

1

2

High-throughput

0.437

High

936059

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

17

High-throughput

0.437

High

936062

GASP1
G-protein coupled receptor-associated sorting protein 1

1

8

Small-scale

0.437

High

155394

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.282

High

936039

TMM62
Transmembrane protein 62

1

0

High-throughput

0.282

High

936048

R3HD1
R3H domain-containing protein 1

1

0

High-throughput

0.282

High

936049

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.282

High

936058

QSER1
Glutamine and serine-rich protein 1

1

0

High-throughput

0.282

High

936086

NBPFF
NBPF family member NBPF15

1

0

High-throughput

0.282

High

936114

ABHEA
Protein ABHD14A

1

0

High-throughput

0.282

High

936134

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.282

High

936137

CRLS1
Cardiolipin synthase

1

0

High-throughput

0.282

High

617495

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

828346

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.279

Low

936071

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

0

High-throughput

0.279

Low

936080

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.279

Low

936085

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

936087

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.279

Low

936101

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.279

Low

936113

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.279

Low

936138

DNM3L
DNA

1

0

Small-scale

0.261

Low

936095

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025