HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22402981
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0032869 - cellular response to insulin stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 536
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (1-531): 0: 569: 55.22
+	Hs
		129163 P85B_HUMAN (1-728): 0: 549: 100.00		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		129169 P85B_HUMAN (1-728): 0: 549: 100.00		LYN_HUMAN (1-531): 0: 532: 52.44
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (30-536): 1.12e-163: 509: 39.45
+	Hs
		129232 P85B_HUMAN (1-728): 0: 549: 100.00		TEC_HUMAN (83-528): 6.43e-155: 458: 37.36
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (1-536): 0: 651: 100.00
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (1-531): 0: 569: 55.22
+	Hs
		433926 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LYN_HUMAN (1-531): 0: 532: 52.44
+	Hs
		846504 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BLK_HUMAN (45-531): 1.62e-179: 516: 57.58
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03
+	Hs
		986388 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BTK_HUMAN (43-527): 1.18e-154: 458: 34.35
+	Hs
		412098 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		FYN_HUMAN (1-536): 0: 598: 68.39
+	Dm
		1360389 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		SRC42_DROME (36-534): 0: 539: 54.21
+	Dm
		337641 ABL_DROME (531-725): 1.27e-32: 138: 20.92		ABL_DROME (13-536): 3.26e-173: 532: 38.53
+	Dm
		337668 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		SRC64_DROME (56-535): 7.2e-178: 514: 51.43
+	Dm
		337669 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		BTKL_DROME (32-519): 1.16e-159: 475: 38.74