HitPredict

Interactor 1: MEG10 (Q96KG7)
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Gene: MEGF10

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 1731
+	Hs
		254237 MEGF6_HUMAN (79-991): 3.19e-78: 284: 22.12		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (4-573): 1.83e-33: 143: 19.22		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		980523 NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (454-991): 2.1e-26: 120: 16.76		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316313 JAG2_HUMAN (476-964): 4.18e-20: 98.9: 12.78		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		61630 MEG11_HUMAN (6-223): 1.02e-17: 91.2: 25.63		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		167042 NOTC3_HUMAN (4-573): 1.83e-33: 143: 19.22		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		166914 NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		1237561 NOTC3_HUMAN (4-573): 1.83e-33: 143: 19.22		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		980449 NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		804293 NOTC1_HUMAN (454-991): 2.1e-26: 120: 16.76		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Mm
		1193399 JAG2_MOUSE (4-591): 6.12e-31: 134: 17.47		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		575654 SERR_DROME (10-440): 1.44e-31: 136: 21.17		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Hs
		944122 JAG1_HUMAN (2-591): 8.18e-27: 120: 17.99		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Dm
		65546 NOTCH_DROME (4-424): 6.71e-17: 88.9: 14.55		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Mm
		1193398 JAG1_MOUSE (3-540): 1.52e-25: 116: 14.57		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		114000 CUBN_DROME (3-271): 3.8e-28: 125: 19.09		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73
+	Dm
		422915 NOTCH_DROME (4-424): 6.71e-17: 88.9: 14.55		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Ce
		81043 CED1_CAEEL (654-1011): 5.06e-21: 101: 20.27		SHANK_CAEEL (1659-1728): 9.7e-09: 62.8: 42.86