HitPredict

Interactor 1: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2, PDZ~PDZ_5
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0044325 - transmembrane transporter binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 817 Hs			1 1190
+	Mm
		1143348 NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1164021 NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21		DLG2_MOUSE (8-534): 5.21e-45: 178: 15.58
+	Mm
		1163969 NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21		DLG1_MOUSE (1-513): 1.74e-44: 177: 16.44
+	Hs
		159249 DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Hs
		159255 ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Hs
		1050411 ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02		MPP2_HUMAN (428-890): 1.51e-90: 305: 16.35
+	Mm
		251104 DLG1_MOUSE (258-621): 4.08e-36: 148: 18.13		CSKP_MOUSE (229-890): 6.48e-93: 321: 15.09
+	Mm
		936181 NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10
+	Rn
		677790 DLG3_RAT (154-707): 1.59e-45: 177: 12.34		DLG4_RAT (3-423): 1.74e-52: 199: 18.89
+	Mm
		936180 DLG3_MOUSE (154-707): 1.11e-45: 178: 12.34		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1119795 Q52KF7_MOUSE (154-707): 1.24e-44: 175: 11.61		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		942364 DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1143369 ERBIN_MOUSE (12-583): 1.18e-43: 173: 13.55		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		1021542 DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Mm
		936188 DLG3_MOUSE (154-707): 1.11e-45: 178: 12.34		DLG2_MOUSE (8-534): 5.21e-45: 178: 15.58
+	Hs
		1077285 DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27		DLG2_HUMAN (8-518): 4.46e-45: 178: 15.49
+	Rn
		1144010 DLG3_RAT (154-707): 1.59e-45: 177: 12.34		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Mm
		1143387 DLG1_MOUSE (258-621): 4.08e-36: 148: 18.13		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Dm
		1214096 Q8IPP3_DROME (479-613): 8.37e-40: 161: 34.07		Q9VHK4_DROME (24-347): 4.82e-23: 108: 21.17
+	Dm
		1096983 Q24279_DROME (347-683): 6.52e-38: 155: 20.61		Q7K4E2_DROME (17-121): 7.61e-13: 75.2: 23.59