Protein: DNJC8
DnaJ homolog subfamily C member 8 (Splicing protein spf31)

Gene: DNJC8, DNAJC8
Organism: Homo sapiens
Interactions: 213
UniProt ID: O75937

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0030544 - Hsp70 protein binding
GO:0045171 - intercellular bridge

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

298352

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.710

High

298438

SRPK1
SRSF protein kinase 1

1

4

High-throughput

0.710

High

270747

ROCK2
Rho-associated protein kinase 2

1

4

High-throughput

0.691

High

298308

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.691

High

298313

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.691

High

298343

RAP1A
Ras-related protein Rap-1A

1

4

High-throughput

0.691

High

298393

PKN2
Serine/threonine-protein kinase N2

1

4

High-throughput

0.691

High

298448

SLK
STE20-like serine/threonine-protein kinase

1

4

High-throughput

0.691

High

298388

SF3A2
Splicing factor 3A subunit 2

4

5

Small-scale

0.686

High

285745

SF3B1
Splicing factor 3B subunit 1

3

2

High-throughput

0.667

High

298389

SF3A1
Splicing factor 3A subunit 1

3

5

High-throughput

0.667

High

298444

NADAP
Kanadaptin

3

1

High-throughput

0.667

High

298345

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.618

High

298423

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.618

High

298459

TBK1
Serine/threonine-protein kinase TBK1

1

3

High-throughput

0.618

High

298281

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

6

High-throughput

0.611

High

298287

RU2B
U2 small nuclear ribonucleoprotein B''

2

3

High-throughput

0.611

High

298468

SF3B6
Splicing factor 3B subunit 6

2

1

High-throughput

0.611

High

298324

RL34
Large ribosomal subunit protein eL34

2

2

High-throughput

0.586

High

298377

SF3B2
Splicing factor 3B subunit 2

2

0

High-throughput

0.585

High

298386

SF3B3
Splicing factor 3B subunit 3

2

0

High-throughput

0.585

High

298426

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.585

High

259231

BRD4
Bromodomain-containing protein 4

2

9

High-throughput

0.584

High

298349

H31
Histone H3.1

2

2

High-throughput

0.584

High

298367

SSRP1
FACT complex subunit SSRP1

2

6

High-throughput

0.584

High

298412

SRRM1
Serine/arginine repetitive matrix protein 1

2

7

High-throughput

0.584

High

298282

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

298471

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.561

High

281840

MPPB
Mitochondrial-processing peptidase subunit beta

2

3

High-throughput

0.558

High

298369

MPPA
Mitochondrial-processing peptidase subunit alpha

2

3

High-throughput

0.558

High

298470

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.553

High

175550

SR140
U2 snRNP-associated SURP motif-containing protein

1

2

High-throughput

0.536

High

219899

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

298292

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.536

High

298301

EGR1
Early growth response protein 1

1

4

High-throughput

0.536

High

298309

U2AF2
Splicing factor U2AF 65 kDa subunit

1

5

High-throughput

0.536

High

298316

FUS
RNA-binding protein FUS

1

4

High-throughput

0.536

High

298338

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.536

High

298346

CANB1
Calcineurin subunit B type 1

1

2

High-throughput

0.536

High

298382

RBM39
RNA-binding protein 39

1

6

High-throughput

0.536

High

298387

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.536

High

298408

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.536

High

298429

SPF45
Splicing factor 45

1

6

High-throughput

0.536

High

298465

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

1

High-throughput

0.536

High

298312

AGTR1
Type-1 angiotensin II receptor

1

2

High-throughput

0.532

High

298325

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.527

High

298296

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

298328

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.515

High

298294

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

298323

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.513

High

298327

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.513

High

298339

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

298371

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.513

High

298397

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

298413

CNTRB
Centrobin

1

0

High-throughput

0.513

High

298435

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

298443

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.513

High

298455

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.513

High

298285

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

298278

CYTN
Cystatin-SN

1

1

High-throughput

0.489

High

298293

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.489

High

298354

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

298358

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.489

High

298384

EMC2
ER membrane protein complex subunit 2

1

7

High-throughput

0.489

High

298416

TTC9C
Tetratricopeptide repeat protein 9C

1

20

High-throughput

0.489

High

298431

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

298446

YTHD1
YTH domain-containing family protein 1

1

4

High-throughput

0.489

High

298419

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

139455

PESC
Pescadillo homolog

1

2

High-throughput

0.479

High

160032

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

1

High-throughput

0.479

High

186966

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.479

High

190767

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

228664

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

7

High-throughput

0.479

High

250377

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.479

High

277485

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.479

High

282641

E2F6
Transcription factor E2F6

1

3

High-throughput

0.479

High

285006

EED
Polycomb protein EED

1

8

High-throughput

0.479

High

298277

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

298279

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

298283

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

298286

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.479

High

298288

ANXA5
Annexin A5

1

1

High-throughput

0.479

High

298289

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

298290

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

298295

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

298297

UBF1
Nucleolar transcription factor 1

1

7

High-throughput

0.479

High

298298

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

298300

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

298303

NUCL
Nucleolin

1

2

High-throughput

0.479

High

298305

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

4

High-throughput

0.479

High

298307

BRD2
Bromodomain-containing protein 2

1

10

High-throughput

0.479

High

298317

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.479

High

298318

SRP14
Signal recognition particle 14 kDa protein

1

2

High-throughput

0.479

High

298319

COIL
Coilin

1

1

High-throughput

0.479

High

298320

CBX5
Chromobox protein homolog 5

1

3

High-throughput

0.479

High

298321

ATRX
Transcriptional regulator ATRX

1

7

High-throughput

0.479

High

298322

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

298330

PPP5
Serine/threonine-protein phosphatase 5

1

2

High-throughput

0.479

High

298331

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

298333

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

High-throughput

0.479

High

298335

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

298337

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

298340

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.479

High

298342

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.479

High

298348

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

298350

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.479

High

298351

RPP30
Ribonuclease P protein subunit p30

1

1

High-throughput

0.479

High

298353

SARNP
SAP domain-containing ribonucleoprotein

1

1

High-throughput

0.479

High

298356

VIGLN
Vigilin

1

1

High-throughput

0.479

High

298357

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

298359

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

298360

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.479

High

298362

RL6
Large ribosomal subunit protein eL6

1

2

High-throughput

0.479

High

298364

CENPC
Centromere protein C

1

4

High-throughput

0.479

High

298365

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

298368

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.479

High

298370

TBL3
Transducin beta-like protein 3

1

11

High-throughput

0.479

High

298372

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

10

High-throughput

0.479

High

298373

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

298374

DDX10
Probable ATP-dependent RNA helicase DDX10

1

3

High-throughput

0.479

High

298375

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.479

High

298378

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

298381

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.479

High

298383

BMS1
Ribosome biogenesis protein BMS1 homolog

1

2

High-throughput

0.479

High

298385

ELOC
Elongin-C

1

1

High-throughput

0.479

High

298392

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

298395

RRP12
RRP12-like protein

1

1

High-throughput

0.479

High

298398

CTR9
RNA polymerase-associated protein CTR9 homolog

1

7

High-throughput

0.479

High

298399

ANR11
Ankyrin repeat domain-containing protein 11

1

17

High-throughput

0.479

High

298401

H2AV
Histone H2A.V

1

3

High-throughput

0.479

High

298403

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.479

High

298405

HDGR2
Hepatoma-derived growth factor-related protein 2

1

4

High-throughput

0.479

High

298406

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

298409

WDR75
WD repeat-containing protein 75

1

8

High-throughput

0.479

High

298411

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.479

High

298425

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

High-throughput

0.479

High

298428

LTV1
Protein LTV1 homolog

1

1

High-throughput

0.479

High

298432

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.479

High

298433

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

16

High-throughput

0.479

High

298434

ZN512
Zinc finger protein 512

1

3

High-throughput

0.479

High

298436

ATAD5
ATPase family AAA domain-containing protein 5

1

6

High-throughput

0.479

High

298440

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

298441

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.479

High

298442

NOC4L
Nucleolar complex protein 4 homolog

1

2

High-throughput

0.479

High

298445

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

3

High-throughput

0.479

High

298447

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

298449

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

6

High-throughput

0.479

High

298450

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.479

High

298452

HELLS
Lymphoid-specific helicase

1

8

High-throughput

0.479

High

298458

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

298460

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

3

High-throughput

0.479

High

298461

RALY
RNA-binding protein Raly

1

1

High-throughput

0.479

High

298462

WDR3
WD repeat-containing protein 3

1

13

High-throughput

0.479

High

298463

SRRM2
Serine/arginine repetitive matrix protein 2

1

7

High-throughput

0.479

High

298466

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

1

High-throughput

0.479

High

298467

WBP11
WW domain-binding protein 11

1

5

High-throughput

0.479

High

284494

TNR21
Tumor necrosis factor receptor superfamily member 21

1

5

High-throughput

0.470

High

140688

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

184358

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.458

High

298299

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

298302

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.458

High

298306

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

298310

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

298314

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

298315

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

298326

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

298329

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.458

High

298332

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

298334

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

298336

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

298341

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

298344

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

298347

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

298355

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.458

High

298363

TOP2B
DNA topoisomerase 2-beta

1

0

High-throughput

0.458

High

298366

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

298376

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

298379

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

298380

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

298394

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.458

High

298404

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

298410

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

298417

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.458

High

298421

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

High-throughput

0.458

High

298422

H1X
Histone H1.10

1

0

High-throughput

0.458

High

298439

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

298453

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

298456

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

298464

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

298469

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

298291

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

298390

SF01
Splicing factor 1

1

1

High-throughput

0.445

High

298407

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

298427

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

298280

SOMA
Somatotropin

1

1

High-throughput

0.437

High

298284

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

298304

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.437

High

298311

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.437

High

298361

NUCB1
Nucleobindin-1

1

4

High-throughput

0.437

High

298400

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

298402

NOL8
Nucleolar protein 8

1

1

High-throughput

0.437

High

298414

LRC47
Leucine-rich repeat-containing protein 47

1

1

High-throughput

0.437

High

298424

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.437

High

298454

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

298457

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

298391

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

298396

Q5TBM3
Heat shock protein family H

1

15

High-throughput

0.407

High

298430

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.407

High

298418

GPT11
G patch domain-containing protein 11

2

0

High-throughput

0.328

High

298415

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

298420

NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8

1

0

High-throughput

0.279

Low

298437

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.279

Low

298451

F204A
Protein FAM204A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025