HitPredict

Interactor 1: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15

Interactor 2: RMD5A (Q9H871)
E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)
Gene: RMND5A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 308 Hs			1 391
+	Hs
		1291935 GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00		RMD5B_HUMAN (1-391): 2.2e-152: 437: 69.72
+	Hs
		351454 TGFB1_HUMAN (33-307): 7.59e-61: 200: 21.48		RMD5A_HUMAN (1-391): 2.58e-160: 457: 100.00
+	Hs
		1185143 GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00		MAEA_HUMAN (25-390): 1.22e-111: 334: 20.05
+	Hs
		1307547 GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00		GID8_HUMAN (114-280): 5.61e-39: 141: 17.54
+	Hs
		1301766 GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00		RANB9_HUMAN (87-214): 3.61e-11: 66.7: 16.41
+	Hs
		351441 TGFB1_HUMAN (33-307): 7.59e-61: 200: 21.48		RANB9_HUMAN (87-214): 3.61e-11: 66.7: 16.41