HitPredict

Interactor 1: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Interactor 2: HIPK2 (Q9H2X6)
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Gene: HIPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 1198
+	Mm
		1322213 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		MINK1_MOUSE (176-1175): 1.13e-147: 480: 14.08
+	Hs
		129042 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		PLK4_HUMAN (194-1163): 1.15e-122: 404: 12.76
+	Mm
		949320 FKB15_MOUSE (57-633): 4.71e-34: 141: 12.89		TNIK_MOUSE (178-1175): 7.95e-142: 464: 11.89
+	Mm
		892970 LZTS1_MOUSE (26-640): 2.9e-33: 137: 34.14		TNIK_MOUSE (178-1175): 7.95e-142: 464: 11.89
+	Mm
		949410 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		TNIK_MOUSE (178-1175): 7.95e-142: 464: 11.89
+	Mm
		57136 LZTS3_MOUSE (1-669): 3.91e-31: 131: 31.62		TNIK_MOUSE (178-1175): 7.95e-142: 464: 11.89
+	Hs
		1268586 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		DYRK2_HUMAN (160-606): 2.42e-117: 379: 31.04
+	Hs
		647995 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		MARK3_HUMAN (145-873): 1.85e-129: 416: 14.40
+	Mm
		659469 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		KCC2B_MOUSE (193-767): 1.55e-131: 414: 16.47
+	Hs
		1183156 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		MARK2_HUMAN (146-873): 2.07e-125: 406: 14.50
+	Mm
		1265874 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		KCC2G_MOUSE (193-767): 3.98e-130: 410: 16.01
+	Mm
		682126 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		AKT1_MOUSE (30-516): 8.46e-122: 386: 16.47
+	Hs
		415112 LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06		CDK1_HUMAN (196-530): 5.99e-119: 372: 24.27
+	Hs
		1044103 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Hs
		1310236 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		DYR1B_HUMAN (199-530): 8.9e-55: 204: 36.31
+	Hs
		1044285 LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Mm
		1142388 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		DYR1A_MOUSE (197-530): 9.5e-56: 210: 39.30
+	Hs
		230539 LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Hs
		230558 LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62		DYR1B_HUMAN (199-530): 8.9e-55: 204: 36.31
+	Hs
		833844 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		CLK1_HUMAN (195-529): 1.92e-44: 170: 30.97