HitPredict

Interactor 1: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Interactor 2: RNF41 (Q9H4P4)
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
Gene: RNF41

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 29560723
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 317
+	Hs
		1331818 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		RNF41_HUMAN (1-317): 4.87e-90: 273: 100.00
+	Hs
		165781 N4BP3_HUMAN (17-640): 5.23e-34: 139: 27.16		RNF41_HUMAN (1-317): 4.87e-90: 273: 100.00
+	Hs
		537021 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		TRI27_HUMAN (3-275): 1.78e-47: 168: 14.75
+	Hs
		1310203 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		TRIM1_HUMAN (2-299): 7.77e-40: 150: 16.57
+	Hs
		129592 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		TRAF5_HUMAN (8-132): 5.62e-29: 118: 29.13
+	Hs
		1078906 ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88		TRIM5_HUMAN (11-298): 1.5e-56: 192: 19.19
+	Hs
		1356051 LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06		TRIM1_HUMAN (2-299): 7.77e-40: 150: 16.57
+	Hs
		584960 DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41		RO52_HUMAN (3-295): 1.95e-61: 204: 16.94
+	Hs
		584968 PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77		RO52_HUMAN (3-295): 1.95e-61: 204: 16.94
+	Hs
		584985 CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52		RO52_HUMAN (3-295): 1.95e-61: 204: 16.94
+	Hs
		1019301 DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41		TRI26_HUMAN (3-301): 1.09e-51: 180: 12.62
+	Hs
		1252557 LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06		LNX1_HUMAN (8-121): 1.33e-26: 111: 27.27
+	Mm
		1111925 SMCA4_MOUSE (18-526): 1.74e-30: 130: 12.69		TRAF3_MOUSE (6-132): 9.1e-28: 114: 24.62
+	Mm
		1150294 SMCA2_MOUSE (18-531): 2.04e-34: 142: 14.48		RN138_MOUSE (1-108): 4.72e-24: 99.8: 22.52
+	Mm
		250627 PHLB1_MOUSE (8-631): 1.39e-27: 121: 11.73		LNX1_MOUSE (7-121): 8.67e-27: 112: 29.51
+	Hs
		536877 CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52		TRI27_HUMAN (3-275): 1.78e-47: 168: 14.75
+	Mm
		1111965 SMCA4_MOUSE (18-526): 1.74e-30: 130: 12.69		RN138_MOUSE (1-108): 4.72e-24: 99.8: 22.52
+	Hs
		1136122 CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52		RC3H1_HUMAN (14-317): 1.43e-39: 150: 16.17
+	Hs
		61867 CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48		LNX1_HUMAN (8-121): 1.33e-26: 111: 27.27
+	Hs
		1012561 CGNL1_HUMAN (321-645): 5.23e-13: 74.7: 21.88		TRAF7_HUMAN (8-137): 1.59e-23: 102: 21.77