HitPredict

Interactor 1: KRIT1 (O00522)
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
Gene: KRIT1

Interactor 2: HEG1 (Q9ULI3)
Protein HEG homolog 1
Gene: HEG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	28514442, 33961781, 23007647
Identification Methods	affinity chromatography technology, isothermal titration calorimetry, x-ray crystallography, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005911 - cell-cell junction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 1381
+	Hs
		980449 ANR44_HUMAN (5-652): 5.5e-83: 285: 10.87		NOTC2_HUMAN (738-1311): 5.8e-39: 161: 10.39
+	Hs
		804293 ANR44_HUMAN (5-652): 5.5e-83: 285: 10.87		NOTC1_HUMAN (687-1200): 6.36e-19: 95.9: 11.11
+	Hs
		1237561 ANR44_HUMAN (5-652): 5.5e-83: 285: 10.87		NOTC3_HUMAN (963-1241): 2e-16: 87.6: 15.20
+	Hs
		166914 ANR28_HUMAN (1-341): 2.52e-41: 165: 10.41		NOTC2_HUMAN (738-1311): 5.8e-39: 161: 10.39
+	Dm
		246781 Q0KIE7_DROME (233-724): 1.45e-61: 227: 12.57		TENM_DROME (748-1006): 6.62e-15: 82.8: 4.80
+	Hs
		1167037 TNKS2_HUMAN (233-681): 2.54e-64: 234: 14.70		FAT4_HUMAN (895-1054): 1.63e-12: 74.8: 17.39
+	Dm
		65546 A8JNM5_DROME (5-307): 5.8e-42: 167: 10.20		NOTCH_DROME (725-1230): 2.06e-25: 117: 9.96
+	Hs
		167042 ANR28_HUMAN (1-341): 2.52e-41: 165: 10.41		NOTC3_HUMAN (963-1241): 2e-16: 87.6: 15.20
+	Hs
		296661 ANR12_HUMAN (256-406): 2.49e-34: 143: 29.41		SLIT2_HUMAN (1026-1143): 6.78e-12: 72.8: 9.84
+	Hs
		296660 Q6PG48_HUMAN (188-362): 2.36e-20: 94.9: 17.71		SLIT2_HUMAN (1026-1143): 6.78e-12: 72.8: 9.84
+	Hs
		946074 KDIS_HUMAN (10-185): 4.87e-12: 71.8: 10.33		DLK1_HUMAN (989-1055): 1.24e-10: 67: 40.85